en
Scientific article
Open access
English

Characteristics and outcome of prostate cancer with PSA <4 ng/ml at diagnosis: a population-based study

Published inClinical & translational oncology, vol. 11, no. 5, p. 312-317
Collection
  • Open Access - Licence nationale Springer
Publication date2009
Abstract

This population-based study aims to assess prognosis of prostate cancer diagnosed with prostate-specific antigen (PSA) levels <4 ng/ml in routine care. Materials and methods We compared prostate cancer patients with low PSA values (n=59) with other prostate cancer patients (n=1330) by logistic regression and the Cox model using data from the Geneva Cancer Registry. Results Patients with low PSA values more frequently had early-stage and well differentiated tumours. Nevertheless, 35% presented with aggressive tumour characteristics or metastases. After adjustment for other prognostic factors, prostate cancer-specific mortality was similar for both groups (hazard ratio: 1.1; 95%CI: 0.6-2.2). Conclusion We conclude that cancer with low PSA values at diagnosis is not indolent.

Keywords
  • Aged
  • Aged, 80 and over
  • Case-Control Studies
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Prognosis
  • Prostate-Specific Antigen/blood
  • Prostatic Neoplasms/blood/mortality/pathology
  • Survival Analysis
Citation (ISO format)
BONET, Marta et al. Characteristics and outcome of prostate cancer with PSA &lt;4 ng/ml at diagnosis: a population-based study. In: Clinical & translational oncology, 2009, vol. 11, n° 5, p. 312–317. doi: 10.1007/s12094-009-0359-1
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Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal1699-048X
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