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Title

Characteristics and outcome of prostate cancer with PSA <4 ng/ml at diagnosis: a population-based study

Authors
Bonet, Marta
Neyroud, Issabelle
Published in Clinical and Translational Oncology. 2009, vol. 11, no. 5, p. 312-7
Abstract This population-based study aims to assess prognosis of prostate cancer diagnosed with prostate-specific antigen (PSA) levels <4 ng/ml in routine care. Materials and methods We compared prostate cancer patients with low PSA values (n=59) with other prostate cancer patients (n=1330) by logistic regression and the Cox model using data from the Geneva Cancer Registry. Results Patients with low PSA values more frequently had early-stage and well differentiated tumours. Nevertheless, 35% presented with aggressive tumour characteristics or metastases. After adjustment for other prognostic factors, prostate cancer-specific mortality was similar for both groups (hazard ratio: 1.1; 95%CI: 0.6-2.2). Conclusion We conclude that cancer with low PSA values at diagnosis is not indolent.
Keywords AgedAged, 80 and overCase-Control StudiesHumansMaleMiddle AgedNeoplasm StagingPrognosisProstate-Specific Antigen/bloodProstatic Neoplasms/blood/mortality/pathologySurvival Analysis
Identifiers
PMID: 19451064
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Research groups Groupe Bouchardy Magnin Christine (Registre genevois des tumeurs) (532)
Groupe Mirabell Raymond (radio-oncologie) (685)
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BONET, Marta et al. Characteristics and outcome of prostate cancer with PSA <4 ng/ml at diagnosis: a population-based study. In: Clinical and Translational Oncology, 2009, vol. 11, n° 5, p. 312-7. https://archive-ouverte.unige.ch/unige:5652

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Deposited on : 2010-03-30

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