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Title

Priming of immune responses to hepatitis B surface antigen in young mice immunized in the presence of maternally derived antibodies

Authors
Weeratna, RD
Brazolot Millan, CL
McCluskie, M J
Davis, H L
Published in FEMS Immunology and Medical Microbiology. 2001, vol. 30, no. 3, p. 241-7
Abstract Early vaccination is necessary to protect infants from various infectious diseases. However, this is often unsuccessful largely due to the immaturity of the neonatal immune system. Furthermore, maternally derived antibodies can interfere with active immunization. We have previously shown in young mice that immune responses against several different antigens can be improved by the addition of oligodeoxynucleotides containing immunostimulatory CpG motifs (CpG ODN). In this study we have evaluated immunization of newborn (1-7-day-old) BALB/c mice against hepatitis B surface antigen (HBsAg), with alum and/or CpG ODN, in the presence of high levels of maternal antibody against HBsAg (anti-HBs). Seroconversion rates and anti-HBs titers were compared to those induced by a HBsAg-expressing plasmid, since other studies had suggested DNA vaccines to be superior to protein vaccines in young mice with maternal antibody. HBsAg/alum/CpG ODN was superior to DNA vaccine in inducing HBsAg-specific CTL responses in young mice in the presence of maternally transferred anti-HBs antibodies. However, B cell responses to both HBsAg/alum/CpG ODN and DNA vaccines remained weak in the presence of maternally transferred anti-HBs antibodies.
Keywords Adjuvants, Immunologic/administration & dosageAlum Compounds/administration & dosageAnimalsAnimals, NewbornDNA/administration & dosageFemaleHepatitis B Antibodies/analysis/immunologyHepatitis B Surface Antigens/immunologyHepatitis B Vaccines/administration & dosage/immunologyImmunity, Maternally-Acquired/immunologyImmunizationMaleMiceMice, Inbred BALB COligodeoxyribonucleotidesT-Lymphocytes, Cytotoxic/immunologyVaccines, DNA/administration & dosage/immunologyVaccines, Synthetic/administration & dosage/immunology
Identifiers
PMID: 11335145
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Article (Published version) (465 Kb) - public document Free access
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Research group Centre de Vaccinologie et d'Immunologie néonatale (177)
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WEERATNA, RD et al. Priming of immune responses to hepatitis B surface antigen in young mice immunized in the presence of maternally derived antibodies. In: FEMS Immunology and Medical Microbiology, 2001, vol. 30, n° 3, p. 241-7. https://archive-ouverte.unige.ch/unige:56145

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Deposited on : 2015-05-13

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