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Aerosolized iloprost induces a mild but sustained inhibition of platelet aggregation

Contributors

Beghetti, Maurice; Reber, Guido; De Moerloose, Philippe; Vadas, Laszlo; Chiappe, A; Spahr-Schopfer, Isabelle; Rimensberger, Peter

Published in

The European respiratory journal, vol. 19, no. 3, p. 518-524

Publication date

2002

Abstract

Pathological studies have revealed that one of the main features encountered in the pulmonary vasculature of patients with pulmonary hypertension is the presence of thrombotic lesions. Open pilot studies have indicated that aerosolized iloprost may have beneficial effects in patients with pulmonary hypertension. The effects of aerosolized iloprost on platelet function and plasma cyclic adenosine monophosphate (cAMP) were studied. Platelet aggregation and plasma cAMP were measured at baseline, 30 min, 4 and 6 h after inhalation of 15 microg iloprost in 10 healthy volunteers. Maximal platelet aggregation in response to adenosine diphosphate (ADP) (2 and 6 micromol x L(-1)), collagen (2.5 and 5 microg x mL(-1)), epinephrine (1.25 and 5 micromol x L(-1)) and arachidonic acid (0.5 mg x mL(-1)) was measured. Platelet aggregation was significantly inhibited at 30 min in response to ADP (2 and 6 micromol x L(-1), epinephrine (1.25 and 5 micromol x L(-1)) and collagen (2.5 microg x mL(-1)). It was still inhibited at 4 h in response to the same agents, but normalized at 6 h. cAMP increased at 30 min, from 27.3+/-1.2 to 31.8+/-1.2 nmol x L(-1), remained increased at 4 h (29.2+/-1.3 nmol x L(-1)) and normalized at 6 h (27.4+/-1.1 nmol x L(-1)). Aerosolized iloprost induced a mild but sustained inhibition of platelet aggregation. Platelet aggregation inhibition may be one of the mechanisms which explains the beneficial effect of repeated inhalation of iloprost in pulmonary hypertension.

Keywords

  • Administration, Inhalation
  • Adult
  • Analysis of Variance
  • Blood Pressure Determination
  • Cyclic AMP/analysis
  • Dose-Response Relationship, Drug
  • Female
  • Heart Rate
  • Humans
  • Iloprost/administration & dosage
  • Male
  • Middle Aged
  • Platelet Aggregation/drug effects
  • Platelet Function Tests
  • Probability
  • Reference Values

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

BEGHETTI, Maurice et al. Aerosolized iloprost induces a mild but sustained inhibition of platelet aggregation. In: The European respiratory journal, 2002, vol. 19, n° 3, p. 518–524. doi: 10.1183/09031936.02.00094302

Main files (1)

Article (Published version)

Identifiers

Journal ISSN

0903-1936
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814downloads

Technical informations

Creation

23/04/2015 12:52:00

First validation

23/04/2015 12:52:00

Update

14/03/2023 23:15:41

Status update

14/03/2023 23:15:41

Last indexation

31/10/2024 00:09:05
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