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Title

Early onset and rapidly progressive subacute sclerosing panencephalitis after congenital measles infection

Authors
Cruzado, Dounia
Published in European Journal of Pediatrics. 2002, vol. 161, no. 8, p. 438-41
Abstract We report an 18-month-old girl with rapidly progressive subacute sclerosing panencephalitis, whose non immunised mother had measles at the time of delivery. The patient presented with repetitive episodes of myoclonic jerks of the head and arms, followed by a drop of head and trunk with frequent falls. EEG, CSF studies and MRI confirmed the diagnosis. Despite therapy with isoprinosine and valproate, seizure activity continued and she became vegetative within 2 months, with severe spasticity and swallowing difficulties, and died at the age of 28 months. Early age of onset and rapid progression were most likely related to haematogenous in utero acquisition of the measles virus prior to delivery, as well as immaturity of neuronal and immune systems.
Keywords Age of OnsetAnticonvulsants/therapeutic useAntiviral Agents/therapeutic useDisease ProgressionElectroencephalographyFatal OutcomeFemaleHumansInfantInfectious Disease Transmission, VerticalInosine Pranobex/therapeutic useMagnetic Resonance ImagingMeasles/congenital/transmissionMyoclonus/virologyRisk FactorsSubacute Sclerosing Panencephalitis/diagnosis/drug therapy/virologyValproic Acid/therapeutic use
Identifiers
PMID: 12172828
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CRUZADO, Dounia et al. Early onset and rapidly progressive subacute sclerosing panencephalitis after congenital measles infection. In: European Journal of Pediatrics, 2002, vol. 161, n° 8, p. 438-41. https://archive-ouverte.unige.ch/unige:56033

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Deposited on : 2015-05-05

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