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Scientific article
English

Liver transplantation for hepatocellular carcinoma

Contributors

Bismuth, Henri; Majno, Pietro; Adam, René

Published in

Seminars in liver disease, vol. 19, no. 3, p. 311-322

Publication date

1999

Abstract

Liver transplantation for hepatocellular carcinoma (HCC) in patients with cirrhosis is a radical treatment of the tumor and associated precancerous state. It is potentially curative in a proportion of patients. The outcomes of early studies of liver transplantation in this indication were initially unfavorable. Selection of transplant candidates at an early stage, in the absence of extrahepatic spread, gives better survival than surgical resection and alternative nonsurgical treatments. Transarterial chemoembolization can be used for preoperative control of the disease. Adjuvant chemotherapy may be indicated in the postoperative period for the prevention of recurrence in patients with histologic features of invasiveness in the surgical specimen. Liver transplantation as the treatment of choice for early HCC in screening programs in cirrhotic patients may become limited by graft availability as the numbers of hepatitis C-related cases increase. Resection may be indicated if the waiting time is likely to be long.

Keywords

  • Adolescent
  • Adult
  • Aged
  • Carcinoma, Hepatocellular/mortality/secondary/surgery
  • Female
  • Hepatectomy
  • Humans
  • Liver Neoplasms/mortality/surgery
  • Liver Transplantation/methods
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local
  • Risk Factors
  • Survival Rate

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

BISMUTH, Henri, MAJNO, Pietro, ADAM, René. Liver transplantation for hepatocellular carcinoma. In: Seminars in liver disease, 1999, vol. 19, n° 3, p. 311–322. doi: 10.1055/s-2007-1007120

Main files (1)

Article (Published version)

Identifiers

Journal ISSN

0272-8087
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Technical informations

Creation

30/04/2015 11:58:00

First validation

30/04/2015 11:58:00

Update

06/01/2026 14:03:49

Status update

06/01/2026 14:03:49

Last indexation

06/01/2026 14:03:52
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