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Title

Clinical usefulness of therapeutic concentration monitoring for imatinib dosage individualization: results from a randomized controlled trial

Authors
Gotta, V
Widmer, N
Decosterd, L A
Heim, D
Gregor, M
Benz, R
Leoncini-Franscini, L
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Published in Cancer Chemotherapy and Pharmacology. 2014, vol. 74, no. 6, p. 1307-19
Abstract This study assessed whether a cycle of "routine" therapeutic drug monitoring (TDM) for imatinib dosage individualization, targeting an imatinib trough plasma concentration (C min) of 1,000 ng/ml (tolerance: 750-1,500 ng/ml), could improve clinical outcomes in chronic myelogenous leukemia (CML) patients, compared with TDM use only in case of problems ("rescue" TDM).
Keywords AdultAgedAntineoplastic Agents/administration & dosage/pharmacokinetics/therapeutic useBenzamides/administration & dosage/pharmacokinetics/therapeutic useDose-Response Relationship, DrugDrug Monitoring/methodsFemaleFollow-Up StudiesHumansIndividualized Medicine/methodsLeukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy/pathologyMaleMiddle AgedPiperazines/administration & dosage/pharmacokinetics/therapeutic useProspective StudiesPyrimidines/administration & dosage/pharmacokinetics/therapeutic useTreatment Outcome
Identifiers
PMID: 25297989
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Structures
Research group Groupe Lecompte Thomas Pierre (hématologie) (918)
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GOTTA, V et al. Clinical usefulness of therapeutic concentration monitoring for imatinib dosage individualization: results from a randomized controlled trial. In: Cancer Chemotherapy and Pharmacology, 2014, vol. 74, n° 6, p. 1307-19. https://archive-ouverte.unige.ch/unige:55998

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Deposited on : 2015-05-04

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