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Title

Role of endogenous histamine in altered lung mechanics in rabbits

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Published in Anesthesiology. 2002, vol. 96, no. 2, p. 409-15
Abstract Unlike the effects of exogenous histamine, those of endogenous histamine on the lung mechanics have not yet been characterized. The site of endogenous histamine liberation by mivacurium was determined, as were the effects of this histamine on the airway and parenchymal mechanics in control rabbits (group C) and rabbits pretreated with H1 and H2 receptor blockers (group AH). The effectiveness of the receptor blockade was ensured by challenges with exogenous histamine.
Keywords Airway Resistance/drug effects/physiologyAlgorithmsAnimalsBlood Pressure/drug effectsHistamine/blood/pharmacology/physiologyHistamine Antagonists/pharmacologyIsoquinolines/pharmacologyLung/drug effects/physiologyMaleModels, BiologicalNeuromuscular Nondepolarizing Agents/pharmacologyPulmonary Circulation/drug effectsRabbitsRespiratory Mechanics/drug effects/physiology
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PMID: 11818775
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Research group Enfants et hyperréactivité bronchique (69)
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HABRE, Walid et al. Role of endogenous histamine in altered lung mechanics in rabbits. In: Anesthesiology, 2002, vol. 96, n° 2, p. 409-15. https://archive-ouverte.unige.ch/unige:55978

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Deposited on : 2015-04-30

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