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Role of endogenous histamine in altered lung mechanics in rabbits

ContributorsHabre, Walid; Babik, Barna; Chalier, Michel; Petak, Ferenc
Published inAnesthesiology, vol. 96, no. 2, p. 409-415
Publication date2002
Abstract

Unlike the effects of exogenous histamine, those of endogenous histamine on the lung mechanics have not yet been characterized. The site of endogenous histamine liberation by mivacurium was determined, as were the effects of this histamine on the airway and parenchymal mechanics in control rabbits (group C) and rabbits pretreated with H1 and H2 receptor blockers (group AH). The effectiveness of the receptor blockade was ensured by challenges with exogenous histamine.

Keywords
  • Airway Resistance/drug effects/physiology
  • Algorithms
  • Animals
  • Blood Pressure/drug effects
  • Histamine/blood/pharmacology/physiology
  • Histamine Antagonists/pharmacology
  • Isoquinolines/pharmacology
  • Lung/drug effects/physiology
  • Male
  • Models, Biological
  • Neuromuscular Nondepolarizing Agents/pharmacology
  • Pulmonary Circulation/drug effects
  • Rabbits
  • Respiratory Mechanics/drug effects/physiology
Affiliation entities
Research groups
Citation (ISO format)
HABRE, Walid et al. Role of endogenous histamine in altered lung mechanics in rabbits. In: Anesthesiology, 2002, vol. 96, n° 2, p. 409–415. doi: 10.1097/00000542-200202000-00028
Main files (1)
Article (Published version)
accessLevelPublic
Identifiers
Additional URL for this publicationhttp://anesthesiology.pubs.asahq.org/Article.aspx?articleid=1944735
Journal ISSN0003-3022
587views
445downloads

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Creation23/04/2015 14:08:00
First validation23/04/2015 14:08:00
Update12/03/2026 10:37:29
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