Mitochondrial dysfunction contributes to impaired insulin secretion in INS-1 cells with dominant-negative mutations of HNF-1alpha and in HNF-1alpha-deficient islets
Publié dansThe Journal of biological chemistry, vol. 284, no. 25, p. 16808-16821
Date de publication2009
Résumé
Mots-clés
- Adenosine Triphosphate/biosynthesis
- Animals
- Base Sequence
- Cell Line
- DNA Primers/genetics
- Diabetes Mellitus, Type 2/genetics/physiopathology
- Female
- Glucose/pharmacology
- Glucose Transporter Type 2/genetics
- Glutamine/pharmacology
- Glycolysis
- Hepatocyte Nuclear Factor 1-alpha/deficiency/genetics/metabolism
- Humans
- Insulin/secretion
- Islets of Langerhans/drug effects/metabolism/secretion
- Leucine/pharmacology
- Male
- Mice
- Mice, Knockout
- Mitochondria/drug effects/metabolism
- Mutation
- Oxidative Phosphorylation
- Pyruvic Acid/pharmacology
- RNA, Messenger/genetics/metabolism
- Rats
Structure d'affiliation
Citation (format ISO)
PONGRATZ, Rebecca L. et al. Mitochondrial dysfunction contributes to impaired insulin secretion in INS-1 cells with dominant-negative mutations of HNF-1alpha and in HNF-1alpha-deficient islets. In: The Journal of biological chemistry, 2009, vol. 284, n° 25, p. 16808–16821. doi: 10.1074/jbc.M807723200
Fichiers principaux (1)
Article (Published version)
Identifiants
- PID : unige:5585
- DOI : 10.1074/jbc.M807723200
- PMID : 19376774
URL commercialhttp://www.jbc.org/content/284/25/16808.long
ISSN du journal0021-9258