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Title

Von Willebrand factor as a biological sensor of blood flow to monitor percutaneous aortic valve interventions

Authors
Van Belle, Eric
Rauch, Antoine
Vincentelli, André
Jeanpierre, Emmanuelle
Legendre, Paulette
Juthier, Francis
Hurt, Christopher
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Published in Circulation Research. 2015, vol. 116, no. 7, p. 1193-201
Abstract Percutaneous aortic valve procedures are a major breakthrough in the management of patients with aortic stenosis. Residual gradient and residual aortic regurgitation are major predictors of midterm and long-term outcome after percutaneous aortic valve procedures. We hypothesized that (1) induction/recovery of high molecular weight (HMW) multimers of von Willebrand factor defect could be instantaneous after acute changes in blood flow, (2) a bedside point-of-care assay (platelet function analyzer-closure time adenine DI-phosphate [PFA-CADP]), reflecting HMW multimers changes, could be used to monitor in real-time percutaneous aortic valve procedures.
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PMID: 25670067
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Article (Published version) (2 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research groups Chirurgie cardio-vasculaire (105)
Groupe de recherche en hémodynamique (913)
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BANFI, Carlo et al. Von Willebrand factor as a biological sensor of blood flow to monitor percutaneous aortic valve interventions. In: Circulation Research, 2015, vol. 116, n° 7, p. 1193-201. https://archive-ouverte.unige.ch/unige:55620

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Deposited on : 2015-04-20

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