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Aprotinin does not impair renal haemodynamics and function after cardiac surgery

Schweizer, Alexandre
Published in British journal of anaesthesia. 2000, vol. 84, no. 1, p. 16-22
Abstract Patients undergoing cardiac surgery with moderate hypothermic cardiopulmonary bypass (CPB) were allocated randomly to receive either saline (control group, n = 29) or a high-dose regimen of aprotinin (aprotinin group, n = 28). In both groups, CPB was associated with similar and transient increases in effective renal plasma flow (+54% in controls and +48% in aprotinin-treated patients) and in fractional excretion of sodium and potassium, but glomerular filtration rate remained unchanged. Plasma and urinary ratios of 6-keto-PGF1 alpha to thromboxane B2 (TxB2) increased significantly, indicating systemic and renal release of vasodilatory prostaglandins. Osmolar clearance correlated with urinary excretion of cyclic GMP (r = 0.79 and 0.86 in the control and aprotinin groups, respectively) and 6-keto-PGF1 alpha (r = 0.63 and 0.69 in the control and aprotinin groups, respectively). Compared with preoperative values, plasma atrial natriuretic peptide increased after weaning from CPB (+71% and +93% in the control and aprotinin groups, respectively). Aprotinin had no apparent adverse effect on renal function and it did not alter mechanisms involving prostanoids and atrial natriuretic peptide during cardiac surgery.
Keywords 6-Ketoprostaglandin F1 alpha/metabolismAdultAgedAged, 80 and overAprotinin/pharmacologyAtrial Natriuretic Factor/bloodCardiac Surgical ProceduresCardiopulmonary BypassCyclic GMP/metabolismDouble-Blind MethodFemaleHemodynamics/drug effectsHemostatics/pharmacologyHumansKidney/drug effects/physiologyMaleMiddle AgedSerine Proteinase Inhibitors/pharmacologyThromboxane B2/metabolism
PMID: 10740541
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Article (Published version) (113 Kb) - public document Free access
Research groups Chirurgie cardio-vasculaire (105)
Dysfonctions cardio-pulmonaires et cérébrales (278)
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SCHWEIZER, Alexandre et al. Aprotinin does not impair renal haemodynamics and function after cardiac surgery. In: British journal of anaesthesia, 2000, vol. 84, n° 1, p. 16-22. https://archive-ouverte.unige.ch/unige:55522

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Deposited on : 2015-04-14

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