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unige:55522 
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Aprotinin does not impair renal haemodynamics and function after cardiac surgery |
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| Authors | ||
| Published in | British Journal of Anaesthesia. 2000, vol. 84, no. 1, p. 16-22 | |
| Abstract | Patients undergoing cardiac surgery with moderate hypothermic cardiopulmonary bypass (CPB) were allocated randomly to receive either saline (control group, n = 29) or a high-dose regimen of aprotinin (aprotinin group, n = 28). In both groups, CPB was associated with similar and transient increases in effective renal plasma flow (+54% in controls and +48% in aprotinin-treated patients) and in fractional excretion of sodium and potassium, but glomerular filtration rate remained unchanged. Plasma and urinary ratios of 6-keto-PGF1 alpha to thromboxane B2 (TxB2) increased significantly, indicating systemic and renal release of vasodilatory prostaglandins. Osmolar clearance correlated with urinary excretion of cyclic GMP (r = 0.79 and 0.86 in the control and aprotinin groups, respectively) and 6-keto-PGF1 alpha (r = 0.63 and 0.69 in the control and aprotinin groups, respectively). Compared with preoperative values, plasma atrial natriuretic peptide increased after weaning from CPB (+71% and +93% in the control and aprotinin groups, respectively). Aprotinin had no apparent adverse effect on renal function and it did not alter mechanisms involving prostanoids and atrial natriuretic peptide during cardiac surgery. | |
| Keywords | 6-Ketoprostaglandin F1 alpha/metabolism — Adult — Aged — Aged, 80 and over — Aprotinin/pharmacology — Atrial Natriuretic Factor/blood — Cardiac Surgical Procedures — Cardiopulmonary Bypass — Cyclic GMP/metabolism — Double-Blind Method — Female — Hemodynamics/drug effects — Hemostatics/pharmacology — Humans — Kidney/drug effects/physiology — Male — Middle Aged — Serine Proteinase Inhibitors/pharmacology — Thromboxane B2/metabolism | |
| Identifiers | PMID: 10740541 | |
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| Structures | ||
| Research groups | Chirurgie cardio-vasculaire (105) Dysfonctions cardio-pulmonaires et cérébrales (278) | |
| Citation (ISO format) | SCHWEIZER, Alexandre et al. Aprotinin does not impair renal haemodynamics and function after cardiac surgery. In: British Journal of Anaesthesia, 2000, vol. 84, n° 1, p. 16-22. https://archive-ouverte.unige.ch/unige:55522 |
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