Hepatitis B immunisation induces higher antibody and memory Th2 responses in new-borns than in adults

Ota, Martin OC; Vekemans, Johan; Schlegel Heueter, Susanna; Fielding, Katherine; Whittle, Hilton; Lambert, Paul Henri; McAdam, Keith P W J; Siegrist, Claire-Anne; Marchant, Arnaud

doi:10.1016/j.vaccine.2003.07.020

Scientific article

English

Hepatitis B immunisation induces higher antibody and memory Th2 responses in new-borns than in adults

Contributors

Ota, Martin OC; Vekemans, Johan; Schlegel Heueter, Susanna; Fielding, Katherine; Whittle, Hilton; Lambert, Paul Henri; McAdam, Keith P W J; Siegrist, Claire-Anne; Marchant, Arnaud

Published in

Vaccine, vol. 22, no. 3-4, p. 511-519

Publication date

2004

Abstract

New-borns raise limited antibody responses to most T cell-dependent antigens but little is known about neonatal T lymphocyte responses to vaccines. In this study, we compared the immune response induced by the hepatitis B vaccine in new-borns and nai;ve adults. Infants produced markedly higher serum anti-hepatitis B surface (HBs) antibody titres than adults. This was not associated with greater HBs Ag-specific Th2 cytokine responses but with lower primary IFN-gamma responses. At 1 year, the infant memory response to HBs Ag was characterised by higher Th2 responses than those of adults. We conclude that neonatal antibody and T cell responses to hepatitis B vaccine differ from those induced in adults.

Keywords

Adjuvants, Immunologic
Adolescent
Adult
Aging/immunology
BCG Vaccine/immunology
Female
Hepatitis Antibodies/analysis/biosynthesis
Hepatitis B Vaccines/administration & dosage/immunology
Humans
Immunity, Cellular/immunology
Immunization
Immunologic Memory/immunology
Infant
Infant, Newborn
Interferon-gamma/biosynthesis/physiology
Male
Th2 Cells/immunology

UNIGE affiliation entities

UNIGE research groups

Centre de Vaccinologie et d'Immunologie néonatale (177)

Citation (ISO format)

OTA, Martin OC et al. Hepatitis B immunisation induces higher antibody and memory Th2 responses in new-borns than in adults. In: Vaccine, 2004, vol. 22, n° 3-4, p. 511–519. doi: 10.1016/j.vaccine.2003.07.020

Article (Published version)

Identifiers

PID : unige:55495
DOI : 10.1016/j.vaccine.2003.07.020
PMID : 14670334

Journal ISSN

0264-410X

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26/02/2015 10:48:00

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30/10/2024 23:55:55

Hepatitis B immunisation induces higher antibody and memory Th2 responses in new-borns than in adults

Contributors

Published in

Publication date

Abstract

Keywords

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

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Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation