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Hepatitis B immunisation induces higher antibody and memory Th2 responses in new-borns than in adults

Ota, Martin OC
Vekemans, Johan
Fielding, Katherine
Whittle, Hilton
McAdam, Keith P W J
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Published in Vaccine. 2004, vol. 22, no. 3-4, p. 511-9
Abstract New-borns raise limited antibody responses to most T cell-dependent antigens but little is known about neonatal T lymphocyte responses to vaccines. In this study, we compared the immune response induced by the hepatitis B vaccine in new-borns and nai;ve adults. Infants produced markedly higher serum anti-hepatitis B surface (HBs) antibody titres than adults. This was not associated with greater HBs Ag-specific Th2 cytokine responses but with lower primary IFN-gamma responses. At 1 year, the infant memory response to HBs Ag was characterised by higher Th2 responses than those of adults. We conclude that neonatal antibody and T cell responses to hepatitis B vaccine differ from those induced in adults.
Keywords Adjuvants, ImmunologicAdolescentAdultAging/immunologyBCG Vaccine/immunologyFemaleHepatitis Antibodies/analysis/biosynthesisHepatitis B Vaccines/administration & dosage/immunologyHumansImmunity, Cellular/immunologyImmunizationImmunologic Memory/immunologyInfantInfant, NewbornInterferon-gamma/biosynthesis/physiologyMaleTh2 Cells/immunology
PMID: 14670334
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Research group Centre de Vaccinologie et d'Immunologie néonatale (177)
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OTA, Martin OC et al. Hepatitis B immunisation induces higher antibody and memory Th2 responses in new-borns than in adults. In: Vaccine, 2004, vol. 22, n° 3-4, p. 511-9. doi: 10.1016/j.vaccine.2003.07.020 https://archive-ouverte.unige.ch/unige:55495

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Deposited on : 2015-04-13

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