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Effects of volatile anaesthetic agents on enhanced airway tone in sensitized guinea pigs

Schütz, N
Published in British Journal of Anaesthesia. 2004, vol. 92, no. 2, p. 254-60
Abstract Although volatile anaesthetics afford protection against bronchospasm, their potential to reverse a sustained constriction of hyperreactive airways has not been characterized. Accordingly, we investigated the ability of halothane, isoflurane, sevoflurane and desflurane to reverse lung constriction induced by prolonged stimulation of the muscarinic receptors in guinea pigs sensitized to ovalbumin.
Keywords Airway Resistance/drug effectsAnesthetics, Inhalation/pharmacologyAnimalsBronchoconstriction/drug effectsBronchoconstrictor Agents/diagnostic useGuinea PigsHalothane/pharmacologyIsoflurane/analogs & derivatives/pharmacologyLung Compliance/drug effectsMaleMethacholine Chloride/diagnostic useMethyl Ethers/pharmacologyPulmonary Gas Exchange/drug effects
PMID: 14722179
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Research groups Enfants et hyperréactivité bronchique (69)
Facteurs influençants le développement pulmonaire: étude translationnelle chez l'animal et l'homme (182)
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SCHÜTZ, N et al. Effects of volatile anaesthetic agents on enhanced airway tone in sensitized guinea pigs. In: British Journal of Anaesthesia, 2004, vol. 92, n° 2, p. 254-60. doi: 10.1093/bja/aeh049 https://archive-ouverte.unige.ch/unige:55480

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Deposited on : 2015-04-13

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