Effects of volatile anaesthetic agents on enhanced airway tone in sensitized guinea pigs

Schütz, N; Petak, Ferenc; Barazzone, Constance; Fontao, Fabienne; Habre, Walid

doi:10.1093/bja/aeh049

Scientific article

English

Effects of volatile anaesthetic agents on enhanced airway tone in sensitized guinea pigs

ContributorsSchütz, N; Petak, Ferenc; Barazzone, Constance; Fontao, Fabienne; Habre, Walid

Published inBritish journal of anaesthesia, vol. 92, no. 2, p. 254-260

Publication date2004

Abstract

Although volatile anaesthetics afford protection against bronchospasm, their potential to reverse a sustained constriction of hyperreactive airways has not been characterized. Accordingly, we investigated the ability of halothane, isoflurane, sevoflurane and desflurane to reverse lung constriction induced by prolonged stimulation of the muscarinic receptors in guinea pigs sensitized to ovalbumin.

Keywords

Airway Resistance/drug effects
Anesthetics, Inhalation/pharmacology
Animals
Bronchoconstriction/drug effects
Bronchoconstrictor Agents/diagnostic use
Guinea Pigs
Halothane/pharmacology
Isoflurane/analogs & derivatives/pharmacology
Lung Compliance/drug effects
Male
Methacholine Chloride/diagnostic use
Methyl Ethers/pharmacology
Pulmonary Gas Exchange/drug effects

Affiliation entities

Research groups

Citation (ISO format)

SCHÜTZ, N et al. Effects of volatile anaesthetic agents on enhanced airway tone in sensitized guinea pigs. In: British journal of anaesthesia, 2004, vol. 92, n° 2, p. 254–260. doi: 10.1093/bja/aeh049

Article (Published version)

Identifiers

PID : unige:55480
DOI : 10.1093/bja/aeh049
PMID : 14722179

Journal ISSN0007-0912

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Effects of volatile anaesthetic agents on enhanced airway tone in sensitized guinea pigs

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