Genetic deletion of the adaptor protein p66Shc increases susceptibility to short-term ischaemic myocardial injury via intracellular salvage pathways

Akhmedov, Alexander; Montecucco, Fabrizio; Braunersreuther, Vincent; Camici, Giovanni G; Jakob, Philipp; Reiner, Martin F; Glanzmann, Martina; Burger, Fabienne; Paneni, Francesco; Galan, Katia; Pelli, Graziano; Vuilleumier, Nicolas; Belin, Alexandre; Vallée, Jean-Paul; Mach, François; Lüscher, Thomas F

doi:10.1093/eurheartj/ehu400

Scientific article

English

Genetic deletion of the adaptor protein p66Shc increases susceptibility to short-term ischaemic myocardial injury via intracellular salvage pathways

ContributorsAkhmedov, Alexander; Montecucco, Fabrizio; Braunersreuther, Vincent; Camici, Giovanni G; Jakob, Philipp; Reiner, Martin F; Glanzmann, Martina; Burger, Fabienne; Paneni, Francesco; Galan, Katia; Pelli, Graziano; Vuilleumier, Nicolas; Belin, Alexandre; Vallée, Jean-Paul

; Mach, François; Lüscher, Thomas F

Published inEuropean heart journal, vol. 36, no. 8, p. 516-526

Publication date2015

Abstract

Several intracellular mediators have been implicated as new therapeutic targets against myocardial ischaemia and reperfusion injury. However, clinically effective salvage pathways remain undiscovered. Here, we focused on the potential role of the adaptor protein p66(Shc) as a regulator of myocardial injury in a mouse model of cardiac ischaemia and reperfusion.

Affiliation entities

Research groups

Citation (ISO format)

AKHMEDOV, Alexander et al. Genetic deletion of the adaptor protein p66Shc increases susceptibility to short-term ischaemic myocardial injury via intracellular salvage pathways. In: European heart journal, 2015, vol. 36, n° 8, p. 516–526. doi: 10.1093/eurheartj/ehu400

Article (Published version)

Identifiers

PID : unige:55466
DOI : 10.1093/eurheartj/ehu400
PMID : 25336219

Journal ISSN0195-668X

658views

2downloads

Creation02/03/2015 15:11:00

First validation02/03/2015 15:11:00

Update time23/01/2025 11:36:53

Status update23/01/2025 11:36:53

Last indexation23/01/2025 11:44:51

Archive ouverte UNIGE

Genetic deletion of the adaptor protein p66Shc increases susceptibility to short-term ischaemic myocardial injury via intracellular salvage pathways

Technical informations