• Home
  1. Home
  2. Effects of inhaled nitric oxide and intravenous magnesium sulphate, alone and in combination, in a porcine model of hypoxic pulmonary hypertension
Scientific article
English

Effects of inhaled nitric oxide and intravenous magnesium sulphate, alone and in combination, in a porcine model of hypoxic pulmonary hypertension

Contributors

Beghetti, Maurice; Spahr-Schopfer, Isabelle; Mensi, Nouri; Morel, Denis; Rimensberger, Peter

Published in

Medical science monitor, vol. 9, no. 6, p. BR193-198

Publication date

2003

Abstract

In order to compare the effects of inhaled nitric oxide (NO) and magnesium (Mg) and their potential synergism on hemodynamics in pulmonary hypertension, we compared the effect of NO and Mg alone and in combination. The fact that simultaneous administration selectively increases pulmonary vascular relaxation would suggest that their association would allow for a decrease in the NO concentration required for optimal pulmonary vasodilation, thus lowering the risk of side effects.

Keywords

  • Administration, Inhalation
  • Animals
  • Anoxia
  • Cyclic GMP/blood
  • Disease Models, Animal
  • Drug Therapy, Combination
  • Female
  • Heart Rate/drug effects
  • Hypertension, Pulmonary/drug therapy/physiopathology
  • Injections, Intravenous
  • Magnesium/blood
  • Magnesium Sulfate/administration & dosage/therapeutic use
  • Nitric Oxide/administration & dosage/therapeutic use
  • Oxygen/blood
  • Partial Pressure
  • Swine
  • Vascular Resistance/drug effects

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

BEGHETTI, Maurice et al. Effects of inhaled nitric oxide and intravenous magnesium sulphate, alone and in combination, in a porcine model of hypoxic pulmonary hypertension. In: Medical science monitor, 2003, vol. 9, n° 6, p. BR193–198.

Main files (1)

Article (Published version)

Identifiers

Journal ISSN

1234-1010
517views
0downloads

Technical informations

Creation

03/03/2015 13:11:00

First validation

03/03/2015 13:11:00

Update

14/03/2023 23:09:24

Status update

14/03/2023 23:09:24

Last indexation

30/10/2024 23:51:26
All rights reserved by Archive ouverte UNIGE and the University of Geneva
OpenAIRE Indexed & Validated