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Scientific article
English

Effects of inhaled nitric oxide and intravenous magnesium sulphate, alone and in combination, in a porcine model of hypoxic pulmonary hypertension

Published inMedical science monitor, vol. 9, no. 6, p. BR193-198
Publication date2003
Abstract

In order to compare the effects of inhaled nitric oxide (NO) and magnesium (Mg) and their potential synergism on hemodynamics in pulmonary hypertension, we compared the effect of NO and Mg alone and in combination. The fact that simultaneous administration selectively increases pulmonary vascular relaxation would suggest that their association would allow for a decrease in the NO concentration required for optimal pulmonary vasodilation, thus lowering the risk of side effects.

Keywords
  • Administration, Inhalation
  • Animals
  • Anoxia
  • Cyclic GMP/blood
  • Disease Models, Animal
  • Drug Therapy, Combination
  • Female
  • Heart Rate/drug effects
  • Hypertension, Pulmonary/drug therapy/physiopathology
  • Injections, Intravenous
  • Magnesium/blood
  • Magnesium Sulfate/administration & dosage/therapeutic use
  • Nitric Oxide/administration & dosage/therapeutic use
  • Oxygen/blood
  • Partial Pressure
  • Swine
  • Vascular Resistance/drug effects
Citation (ISO format)
BEGHETTI, Maurice et al. Effects of inhaled nitric oxide and intravenous magnesium sulphate, alone and in combination, in a porcine model of hypoxic pulmonary hypertension. In: Medical science monitor, 2003, vol. 9, n° 6, p. BR193–198.
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Article (Published version)
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Identifiers
ISSN of the journal1234-1010
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