Effects of inhaled nitric oxide and intravenous magnesium sulphate, alone and in combination, in a porcine model of hypoxic pulmonary hypertension

Beghetti, Maurice; Spahr-Schopfer, Isabelle; Mensi, Nouri; Morel, Denis; Rimensberger, Peter

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Title		Effects of inhaled nitric oxide and intravenous magnesium sulphate, alone and in combination, in a porcine model of hypoxic pulmonary hypertension
Authors		Beghetti, Maurice Spahr-Schopfer, Isabelle Mensi, Nouri Morel, Denis Rimensberger, Peter
Published in		Medical science monitor. 2003, vol. 9, no. 6, p. BR193-8
Abstract		In order to compare the effects of inhaled nitric oxide (NO) and magnesium (Mg) and their potential synergism on hemodynamics in pulmonary hypertension, we compared the effect of NO and Mg alone and in combination. The fact that simultaneous administration selectively increases pulmonary vascular relaxation would suggest that their association would allow for a decrease in the NO concentration required for optimal pulmonary vasodilation, thus lowering the risk of side effects.
Keywords		Administration, Inhalation — Animals — Anoxia — Cyclic GMP/blood — Disease Models, Animal — Drug Therapy, Combination — Female — Heart Rate/drug effects — Hypertension, Pulmonary/drug therapy/physiopathology — Injections, Intravenous — Magnesium/blood — Magnesium Sulfate/administration & dosage/therapeutic use — Nitric Oxide/administration & dosage/therapeutic use — Oxygen/blood — Partial Pressure — Swine — Vascular Resistance/drug effects
Identifiers		PMID: 12824941
Full text		Article (Published version) (291 Kb) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique
Research groups		L'hypertension pulmonaire (pédiatrie) (228) Maladies pulmonaires aigues et pathologies cardiaques congénitales (697)
Citation (ISO format)		BEGHETTI, Maurice et al. Effects of inhaled nitric oxide and intravenous magnesium sulphate, alone and in combination, in a porcine model of hypoxic pulmonary hypertension. In: Medical science monitor, 2003, vol. 9, n° 6, p. BR193-8. https://archive-ouverte.unige.ch/unige:55334