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Title

Effects of inhaled nitric oxide and intravenous magnesium sulphate, alone and in combination, in a porcine model of hypoxic pulmonary hypertension

Authors
Mensi, Nouri
Published in Medical Science Monitor. 2003, vol. 9, no. 6, p. BR193-8
Abstract In order to compare the effects of inhaled nitric oxide (NO) and magnesium (Mg) and their potential synergism on hemodynamics in pulmonary hypertension, we compared the effect of NO and Mg alone and in combination. The fact that simultaneous administration selectively increases pulmonary vascular relaxation would suggest that their association would allow for a decrease in the NO concentration required for optimal pulmonary vasodilation, thus lowering the risk of side effects.
Keywords Administration, InhalationAnimalsAnoxiaCyclic GMP/bloodDisease Models, AnimalDrug Therapy, CombinationFemaleHeart Rate/drug effectsHypertension, Pulmonary/drug therapy/physiopathologyInjections, IntravenousMagnesium/bloodMagnesium Sulfate/administration & dosage/therapeutic useNitric Oxide/administration & dosage/therapeutic useOxygen/bloodPartial PressureSwineVascular Resistance/drug effects
Identifiers
PMID: 12824941
Full text
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Structures
Research groups L'hypertension pulmonaire (pédiatrie) (228)
Maladies pulmonaires aigues et pathologies cardiaques congénitales (697)
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(ISO format)
BEGHETTI, Maurice et al. Effects of inhaled nitric oxide and intravenous magnesium sulphate, alone and in combination, in a porcine model of hypoxic pulmonary hypertension. In: Medical Science Monitor, 2003, vol. 9, n° 6, p. BR193-8. https://archive-ouverte.unige.ch/unige:55334

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Deposited on : 2015-04-09

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