Homocysteine prevents total parenteral nutrition (TPN)-induced cholestasis without changes in hepatic oxidative stress in the rat

Belli, Dominique Charles; Albrecht, Robert; La Scala, Giorgio; Desjeux, Jehan-François; Pelissier, Marie-Agnes

doi:10.1097/00005176-200302000-00008

Scientific article

English

Homocysteine prevents total parenteral nutrition (TPN)-induced cholestasis without changes in hepatic oxidative stress in the rat

ContributorsBelli, Dominique Charles; Albrecht, Robert; La Scala, Giorgio

; Desjeux, Jehan-François; Pelissier, Marie-Agnes

Published inJournal of pediatric gastroenterology and nutrition, vol. 36, no. 2, p. 200-205

Publication date2003

Abstract

The role of oxidative stress in total parenteral nutrition (TPN)-associated cholestasis with liver glutathione depletion was recently shown. The aims of this study were to test the appearance of cholestasis and oxidative stress during TPN, and the hypothesis that reducing oxidative stress with a precursor of glutathione (GSH), homocysteine, would restore bile flow.

Keywords

Animals
Bile Acids and Salts/metabolism
Cholestasis/chemically induced/etiology/prevention & control
Glutathione/administration & dosage/pharmacology
Homocysteine/administration & dosage/pharmacology/therapeutic use
Infusions, Intravenous
Lipids/administration & dosage
Liver/drug effects/metabolism
Male
Oxidative Stress/drug effects
Parenteral Nutrition, Total/adverse effects
Random Allocation
Rats
Rats, Wistar
Thiobarbituric Acid Reactive Substances/analysis

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

Research groups

Gastroentérologie et transplantation (pédiatrie) (181)

Citation (ISO format)

BELLI, Dominique Charles et al. Homocysteine prevents total parenteral nutrition (TPN)-induced cholestasis without changes in hepatic oxidative stress in the rat. In: Journal of pediatric gastroenterology and nutrition, 2003, vol. 36, n° 2, p. 200–205. doi: 10.1097/00005176-200302000-00008

Article (Published version)

Identifiers

PID : unige:55332
DOI : 10.1097/00005176-200302000-00008
PMID : 12548054

Journal ISSN0277-2116

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Homocysteine prevents total parenteral nutrition (TPN)-induced cholestasis without changes in hepatic oxidative stress in the rat

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