en
Scientific article
English

Homocysteine prevents total parenteral nutrition (TPN)-induced cholestasis without changes in hepatic oxidative stress in the rat

Published inJournal of pediatric gastroenterology and nutrition, vol. 36, no. 2, p. 200-205
Publication date2003
Abstract

The role of oxidative stress in total parenteral nutrition (TPN)-associated cholestasis with liver glutathione depletion was recently shown. The aims of this study were to test the appearance of cholestasis and oxidative stress during TPN, and the hypothesis that reducing oxidative stress with a precursor of glutathione (GSH), homocysteine, would restore bile flow.

Keywords
  • Animals
  • Bile Acids and Salts/metabolism
  • Cholestasis/chemically induced/etiology/prevention & control
  • Glutathione/administration & dosage/pharmacology
  • Homocysteine/administration & dosage/pharmacology/therapeutic use
  • Infusions, Intravenous
  • Lipids/administration & dosage
  • Liver/drug effects/metabolism
  • Male
  • Oxidative Stress/drug effects
  • Parenteral Nutrition, Total/adverse effects
  • Random Allocation
  • Rats
  • Rats, Wistar
  • Thiobarbituric Acid Reactive Substances/analysis
Citation (ISO format)
BELLI, Dominique Charles et al. Homocysteine prevents total parenteral nutrition (TPN)-induced cholestasis without changes in hepatic oxidative stress in the rat. In: Journal of pediatric gastroenterology and nutrition, 2003, vol. 36, n° 2, p. 200–205. doi: 10.1097/00005176-200302000-00008
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0277-2116
519views
0downloads

Technical informations

Creation03/03/2015 1:15:00 PM
First validation03/03/2015 1:15:00 PM
Update time03/14/2023 11:09:23 PM
Status update03/14/2023 11:09:22 PM
Last indexation01/16/2024 5:40:47 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack