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Title

Homocysteine prevents total parenteral nutrition (TPN)-induced cholestasis without changes in hepatic oxidative stress in the rat

Authors
Albrecht, Robert
Desjeux, Jehan-François
Pelissier, Marie-Agnes
Published in Journal of Pediatric Gastroenterology and Nutrition. 2003, vol. 36, no. 2, p. 200-5
Abstract The role of oxidative stress in total parenteral nutrition (TPN)-associated cholestasis with liver glutathione depletion was recently shown. The aims of this study were to test the appearance of cholestasis and oxidative stress during TPN, and the hypothesis that reducing oxidative stress with a precursor of glutathione (GSH), homocysteine, would restore bile flow.
Keywords AnimalsBile Acids and Salts/metabolismCholestasis/chemically induced/etiology/prevention & controlGlutathione/administration & dosage/pharmacologyHomocysteine/administration & dosage/pharmacology/therapeutic useInfusions, IntravenousLipids/administration & dosageLiver/drug effects/metabolismMaleOxidative Stress/drug effectsParenteral Nutrition, Total/adverse effectsRandom AllocationRatsRats, WistarThiobarbituric Acid Reactive Substances/analysis
Identifiers
PMID: 12548054
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Structures
Research group Gastroentérologie et transplantation (pédiatrie) (181)
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(ISO format)
BELLI, Dominique Charles et al. Homocysteine prevents total parenteral nutrition (TPN)-induced cholestasis without changes in hepatic oxidative stress in the rat. In: Journal of Pediatric Gastroenterology and Nutrition, 2003, vol. 36, n° 2, p. 200-5. https://archive-ouverte.unige.ch/unige:55332

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Deposited on : 2015-04-09

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