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Title

CpG-motifs enhance initial and sustained primary tetanus-specific antibody secreting cell responses in spleen and bone marrow, but are more effective in adult than in neonatal mice
Authors
Pihlgren Bosch, Maria Astrid Louise
Tougne, Chantal
Schallert, Nadine
Bozzotti, Paola
Lambert, Paul Henri
Siegrist, Claire-Anne
Published in Vaccine. 2003, vol. 21, no. 19-20, p. 2492-9
Abstract Unmethylated CpG oligonucleotides (CpG-ODN) increase adult and neonatal primary antibody responses to T-dependent antigens, at yet unidentified stages of antigen-specific B cell differentiation. In adult mice, a single dose of CpG-ODN adjuvanted tetanus toxoid (TT) vaccine markedly enhanced and prolonged splenic TT-specific antibody-secreting-cell (ASC) responses and significantly increased the size of the bone marrow (BM) ASC pool. Surprisingly, this was not associated with changes of germinal center (GC) numbers, size, apoptosis or function. In 1-week-old mice, CpG-ODN also enhanced TT-specific splenic ASC responses, but failed to correct limitations of the GC reaction and of the development of the BM ASC pool.
Keywords Aging/immunology — Animals — Animals, Newborn — Antibodies, Bacterial/immunology — Antibody Affinity — Bone Marrow/immunology — Dinucleoside Phosphates/immunology — Enzyme-Linked Immunosorbent Assay — Immunoglobulin G/blood/classification — Mice — Mice, Inbred BALB C — Oligodeoxyribonucleotides/immunology — Spleen/immunology — Tetanus/blood/immunology — Tetanus Toxoid/immunology
Identifiers
PMID: 12744883
Full text
Article (Published version) (174 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie
Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique
Research group Centre de Vaccinologie et d'Immunologie néonatale (177)
Citation
(ISO format) 		PIHLGREN BOSCH, Maria Astrid Louise et al. CpG-motifs enhance initial and sustained primary tetanus-specific antibody secreting cell responses in spleen and bone marrow, but are more effective in adult than in neonatal mice. In: Vaccine, 2003, vol. 21, n° 19-20, p. 2492-9. doi: 10.1016/S0264-410X(03)00052-5 https://archive-ouverte.unige.ch/unige:55314

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Deposited on : 2015-04-09

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