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Title

CpG-motifs enhance initial and sustained primary tetanus-specific antibody secreting cell responses in spleen and bone marrow, but are more effective in adult than in neonatal mice

Authors
Schallert, Nadine
Bozzotti, Paola
Published in Vaccine. 2003, vol. 21, no. 19-20, p. 2492-9
Abstract Unmethylated CpG oligonucleotides (CpG-ODN) increase adult and neonatal primary antibody responses to T-dependent antigens, at yet unidentified stages of antigen-specific B cell differentiation. In adult mice, a single dose of CpG-ODN adjuvanted tetanus toxoid (TT) vaccine markedly enhanced and prolonged splenic TT-specific antibody-secreting-cell (ASC) responses and significantly increased the size of the bone marrow (BM) ASC pool. Surprisingly, this was not associated with changes of germinal center (GC) numbers, size, apoptosis or function. In 1-week-old mice, CpG-ODN also enhanced TT-specific splenic ASC responses, but failed to correct limitations of the GC reaction and of the development of the BM ASC pool.
Keywords Aging/immunologyAnimalsAnimals, NewbornAntibodies, Bacterial/immunologyAntibody AffinityBone Marrow/immunologyDinucleoside Phosphates/immunologyEnzyme-Linked Immunosorbent AssayImmunoglobulin G/blood/classificationMiceMice, Inbred BALB COligodeoxyribonucleotides/immunologySpleen/immunologyTetanus/blood/immunologyTetanus Toxoid/immunology
Identifiers
PMID: 12744883
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Structures
Research group Centre de Vaccinologie et d'Immunologie néonatale (177)
Citation
(ISO format)
PIHLGREN BOSCH, Maria Astrid Louise et al. CpG-motifs enhance initial and sustained primary tetanus-specific antibody secreting cell responses in spleen and bone marrow, but are more effective in adult than in neonatal mice. In: Vaccine, 2003, vol. 21, n° 19-20, p. 2492-9. https://archive-ouverte.unige.ch/unige:55314

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Deposited on : 2015-04-09

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