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Title

Oxidized low-density lipoprotein is associated with apoptosis of vascular smooth muscle cells in human atherosclerotic plaques

Authors
Okura, Y
Brink, M
Itabe, H
Scheidegger, K J
Delafontaine, P
Published in Circulation. 2000, vol. 102, no. 22, p. 2680-6
Abstract Cytotoxic oxidized LDL (oxLDL) has been shown to promote apoptosis in cultured vascular smooth muscle cells (VSMCs). We investigated the localization of oxLDL and its association with apoptosis and the expression of apoptosis-related proteins in early and advanced atherosclerotic lesions.
Keywords Actins/analysisAgedApoptosisArteriosclerosis/metabolism/pathologyBlotting, WesternCell LineFemaleHumansImmunohistochemistryIn Situ Nick-End LabelingLipoproteins, LDL/analysisMaleMuscle, Smooth, Vascular/chemistry/cytologyProto-Oncogene Proteins/analysisProto-Oncogene Proteins c-bcl-2Bcl-2-Associated X Protein
Identifiers
PMID: 11094032
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Article (Published version) (2 MB) - public document Free access
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Research group Chirurgie cardio-vasculaire (105)
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OKURA, Y et al. Oxidized low-density lipoprotein is associated with apoptosis of vascular smooth muscle cells in human atherosclerotic plaques. In: Circulation, 2000, vol. 102, n° 22, p. 2680-6. https://archive-ouverte.unige.ch/unige:55297

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Deposited on : 2015-04-09

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