Oxidized low-density lipoprotein is associated with apoptosis of vascular smooth muscle cells in human atherosclerotic plaques

Okura, Y; Brink, M; Itabe, H; Scheidegger, K J; Kalangos, Afksendiyos; Delafontaine, P

doi:10.1161/01.CIR.102.22.2680

Scientific article

Open access

English

Oxidized low-density lipoprotein is associated with apoptosis of vascular smooth muscle cells in human atherosclerotic plaques

ContributorsOkura, Y; Brink, M; Itabe, H; Scheidegger, K J; Kalangos, Afksendiyos; Delafontaine, P

Published inCirculation, vol. 102, no. 22, p. 2680-2686

Publication date2000

Abstract

Cytotoxic oxidized LDL (oxLDL) has been shown to promote apoptosis in cultured vascular smooth muscle cells (VSMCs). We investigated the localization of oxLDL and its association with apoptosis and the expression of apoptosis-related proteins in early and advanced atherosclerotic lesions.

Keywords

Actins/analysis
Aged
Apoptosis
Arteriosclerosis/metabolism/pathology
Blotting, Western
Cell Line
Female
Humans
Immunohistochemistry
In Situ Nick-End Labeling
Lipoproteins, LDL/analysis
Male
Muscle, Smooth, Vascular/chemistry/cytology
Proto-Oncogene Proteins/analysis
Proto-Oncogene Proteins c-bcl-2
Bcl-2-Associated X Protein

Affiliation

Faculté de médecine / Section de médecine clinique / Département de chirurgie

Research group

Chirurgie cardio-vasculaire (105)

Citation (ISO format)

OKURA, Y et al. Oxidized low-density lipoprotein is associated with apoptosis of vascular smooth muscle cells in human atherosclerotic plaques. In: Circulation, 2000, vol. 102, n° 22, p. 2680–2686. doi: 10.1161/01.CIR.102.22.2680

Article (Published version)

Identifiers

PID : unige:55297
DOI : 10.1161/01.CIR.102.22.2680
PMID : 11094032

ISSN of the journal0009-7322

448views

246downloads

Creation04/08/2015 4:06:00 PM

First validation04/08/2015 4:06:00 PM

Update time03/14/2023 11:09:05 PM

Status update03/14/2023 11:09:05 PM

Last indexation01/16/2024 5:39:58 PM

Archive ouverte UNIGE

Oxidized low-density lipoprotein is associated with apoptosis of vascular smooth muscle cells in human atherosclerotic plaques

Cytotoxic oxidized LDL (oxLDL) has been shown to promote apoptosis in cultured vascular smooth muscle cells (VSMCs). We investigated the localization of oxLDL and its association with apoptosis and the expression of apoptosis-related proteins in early and advanced atherosclerotic lesions.

Technical informations