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Title

Enhanced pulmonary immunopathology following neonatal priming with formalin-inactivated respiratory syncytial virus but not with the BBG2NA vaccine candidate

Authors
Plotnicky, Hélène
Bonnefoy, Jean-Yves
Corvaïa, Nathalie
Nguyen, Thien Ngoc
Power, Ultan F
Published in Vaccine. 2003, vol. 21, no. 19-20, p. 2651-60
Abstract Prevention of respiratory syncytial virus (RSV) disease will implicate neonatal priming. However, neonatal antigen exposure frequently results into Th2-like responses, some of which are critical for formalin-inactivated RSV (FI-RSV)-associated lung immunopathology. Neonatal immunization of mice may thus represent a more stringent model of RSV-enhanced pathology than adults. Indeed, after RSV challenge, lung cell infiltration, lymphocyte activation, and eosinophilia were higher following neonatal compared with adult FI-RSV priming of BALB/c mice. Unexpectedly, similar findings were obtained with Al(OH)(3)-adsorbed live RSV. In contrast, neonatal priming with BBG2Na, a recombinant RSV subunit vaccine candidate, formulated in either Al(OH)(3) or TiterMax (a Th1-driving adjuvant) resulted in predominant Th2- or Th1-like responses, respectively, but never elicited lung immunopathology post-challenge. Importantly, our data emphasize that the induction of Th2-like responses by RSV subunit vaccines do not necessarily imply lung immunopathology.
Keywords AnimalsAnimals, NewbornAntibodies, Viral/bloodCD4-Positive T-Lymphocytes/immunologyEnzyme-Linked Immunosorbent AssayFormaldehydeLung/drug effects/pathologyLymphocyte ActivationMiceMice, Inbred BALB CModels, AnimalRespiratory Syncytial Virus Infections/immunology/pathology/prevention & controlRespiratory Syncytial Virus Vaccines/immunology/toxicityVaccines, Inactivated/immunology/toxicity
Identifiers
PMID: 12744902
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Research group Centre de Vaccinologie et d'Immunologie néonatale (177)
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PLOTNICKY, Hélène et al. Enhanced pulmonary immunopathology following neonatal priming with formalin-inactivated respiratory syncytial virus but not with the BBG2NA vaccine candidate. In: Vaccine, 2003, vol. 21, n° 19-20, p. 2651-60. https://archive-ouverte.unige.ch/unige:55262

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Deposited on : 2015-04-08

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