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Title

Mechanisms by which maternal antibodies influence infant vaccine responses: review of hypotheses and definition of main determinants

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Published in Vaccine. 2003, vol. 21, no. 24, p. 3406-12
Abstract Several mechanisms have been suggested as mediating the inhibitory influence of maternal antibodies (MatAb) on infant responses. This inhibition is B cell determinant-specific, depends on the ratio between MatAb titers at the time of immunization and the dose of vaccine antigen, and leaves infant T cell responses largely unaffected. Neutralization of vaccine replication or FcgammaRIIB-mediated inhibitory signalling to infant B cells would not account for these characteristics. In contrast, determinant-specific masking of B cell epitopes and APC uptake of MatAb:vaccine antigen immune complexes, followed by antigen processing and presentation, explain the pattern of pre-clinical and clinical responses to infant vaccines. This allows the definition of the main determinants of the influence of MatAb on infant immunity.
Keywords AdultAntibodies/immunology/physiologyFemaleHumansImmunity/physiologyInfantInfant, NewbornVaccines/immunologyViral Vaccines/immunology
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PMID: 12850349
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Article (Published version) (140 Kb) - document accessible for UNIGE members only Limited access to UNIGE
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Research group Centre de Vaccinologie et d'Immunologie néonatale (177)
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SIEGRIST, Claire-Anne. Mechanisms by which maternal antibodies influence infant vaccine responses: review of hypotheses and definition of main determinants. In: Vaccine, 2003, vol. 21, n° 24, p. 3406-12. https://archive-ouverte.unige.ch/unige:55254

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Deposited on : 2015-04-08

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