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Seroprevalence of Bordetella pertussis antibodies in Flanders (Belgium)

Van der Wielen, Marie
Van Damme, Pierre
Van Herck, Koen
Published in Vaccine. 2003, vol. 21, no. 19-20, p. 2412-7
Abstract To determine age-dependent pertussis immune response in the Flemish population, antibody levels to pertactin (PRN), pertussis toxin (PT) and filamentous hemagglutinin (FHA) were measured in serum samples from 1622 healthy 1-100-year-old subjects. For anti-PRN and anti-PT antibodies, peaks in GMTs were seen in infancy and again in the 10-15-year age group. After age of 20 years, anti-PRN GMT declined rapidly over a decade, followed by a slower decline. Anti-FHA GMT tended to rather increase progressively with age. These data confirm waning of vaccine-induced antibody levels and suggest pertussis resurgence during adolescence and young adulthood. These results support a pertussis booster vaccination policy for adolescents and adults.
Keywords AdolescentAdultAge DistributionAntibodies, Bacterial/bloodBelgium/epidemiologyChildChild, PreschoolFemaleHumansInfantMaleMiddle AgedReproducibility of ResultsSeroepidemiologic StudiesWhooping Cough/epidemiology
PMID: 12744872
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Research group Centre de Vaccinologie et d'Immunologie néonatale (177)
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VAN DER WIELEN, Marie et al. Seroprevalence of Bordetella pertussis antibodies in Flanders (Belgium). In: Vaccine, 2003, vol. 21, n° 19-20, p. 2412-7. doi: 10.1016/S0264-410X(03)00062-8 https://archive-ouverte.unige.ch/unige:55247

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Deposited on : 2015-04-08

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