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Scientific article
English

Association between busulfan exposure and outcome in children receiving intravenous busulfan before hematopoietic stem cell transplantation

Published inTherapeutic drug monitoring, vol. 36, no. 1, p. 93-99
Publication date2014
Abstract

Intravenous (IV) busulfan (Bu) combined with therapeutic drug monitoring-guided dosing is associated with better event-free survival (EFS), lower transplant-related mortality. But optimal target steady-state concentration (Css) of Bu in children undergoing hematopoietic stem cell transplantation (HSCT) remains unclear. This study aimed to evaluate the relation between Css of Bu and clinical outcomes in children receiving Bu before HSCT.

Keywords
  • Adolescent
  • Antineoplastic Agents, Alkylating/administration & dosage/pharmacokinetics/therapeutic use
  • Blood Specimen Collection
  • Busulfan/administration & dosage/pharmacokinetics/therapeutic use
  • Child
  • Child, Preschool
  • Chromatography, High Pressure Liquid
  • Disease-Free Survival
  • Dose-Response Relationship, Drug
  • Drug Monitoring/methods
  • Female
  • Graft vs Host Disease
  • Hematopoietic Stem Cell Transplantation/methods
  • Humans
  • Infant
  • Infusions, Intravenous
  • Kaplan-Meier Estimate
  • Male
  • Multivariate Analysis
  • Proportional Hazards Models
  • Prospective Studies
  • Survival Rate
  • Time Factors
  • Transplantation Conditioning/methods
  • Treatment Outcome
  • Young Adult
Citation (ISO format)
ANSARI DJABERI, Marc Georges et al. Association between busulfan exposure and outcome in children receiving intravenous busulfan before hematopoietic stem cell transplantation. In: Therapeutic drug monitoring, 2014, vol. 36, n° 1, p. 93–99. doi: 10.1097/FTD.0b013e3182a04fc7
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0163-4356
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