Association between busulfan exposure and outcome in children receiving intravenous busulfan before hematopoietic stem cell transplantation

Ansari Djaberi, Marc Georges; Théoret, Yves; Rezgui, Mohamed Aziz; Peters, Christina; Mezziani, Samira; Desjean, Catherine; Vachon, Marie-France; Champagne, Martin A; Duval, Michel; Krajinovic, Maja; Bittencourt, Henrique

doi:10.1097/FTD.0b013e3182a04fc7

Scientific article

English

Association between busulfan exposure and outcome in children receiving intravenous busulfan before hematopoietic stem cell transplantation

ContributorsAnsari Djaberi, Marc Georges; Théoret, Yves; Rezgui, Mohamed Aziz; Peters, Christina; Mezziani, Samira; Desjean, Catherine; Vachon, Marie-France; Champagne, Martin A; Duval, Michel; Krajinovic, Maja; Bittencourt, Henrique

Published inTherapeutic drug monitoring, vol. 36, no. 1, p. 93-99

Publication date2014

Abstract

Intravenous (IV) busulfan (Bu) combined with therapeutic drug monitoring-guided dosing is associated with better event-free survival (EFS), lower transplant-related mortality. But optimal target steady-state concentration (Css) of Bu in children undergoing hematopoietic stem cell transplantation (HSCT) remains unclear. This study aimed to evaluate the relation between Css of Bu and clinical outcomes in children receiving Bu before HSCT.

Keywords

Adolescent
Antineoplastic Agents, Alkylating/administration & dosage/pharmacokinetics/therapeutic use
Blood Specimen Collection
Busulfan/administration & dosage/pharmacokinetics/therapeutic use
Child
Child, Preschool
Chromatography, High Pressure Liquid
Disease-Free Survival
Dose-Response Relationship, Drug
Drug Monitoring/methods
Female
Graft vs Host Disease
Hematopoietic Stem Cell Transplantation/methods
Humans
Infant
Infusions, Intravenous
Kaplan-Meier Estimate
Male
Multivariate Analysis
Proportional Hazards Models
Prospective Studies
Survival Rate
Time Factors
Transplantation Conditioning/methods
Treatment Outcome
Young Adult

Affiliation

Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

Research group

Oncologie et hématologie pédiatrique (907)

Citation (ISO format)

ANSARI DJABERI, Marc Georges et al. Association between busulfan exposure and outcome in children receiving intravenous busulfan before hematopoietic stem cell transplantation. In: Therapeutic drug monitoring, 2014, vol. 36, n° 1, p. 93–99. doi: 10.1097/FTD.0b013e3182a04fc7

Article (Published version)

Identifiers

PID : unige:55244
DOI : 10.1097/FTD.0b013e3182a04fc7
PMID : 24061446

ISSN of the journal0163-4356

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Association between busulfan exposure and outcome in children receiving intravenous busulfan before hematopoietic stem cell transplantation

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