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Title

Association between busulfan exposure and outcome in children receiving intravenous busulfan before hematopoietic stem cell transplantation

Authors
Théoret, Yves
Rezgui, Mohamed Aziz
Peters, Christina
Mezziani, Samira
Desjean, Catherine
Vachon, Marie-France
Champagne, Martin A
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Published in Therapeutic Drug Monitoring. 2014, vol. 36, no. 1, p. 93-9
Abstract Intravenous (IV) busulfan (Bu) combined with therapeutic drug monitoring-guided dosing is associated with better event-free survival (EFS), lower transplant-related mortality. But optimal target steady-state concentration (Css) of Bu in children undergoing hematopoietic stem cell transplantation (HSCT) remains unclear. This study aimed to evaluate the relation between Css of Bu and clinical outcomes in children receiving Bu before HSCT.
Keywords AdolescentAntineoplastic Agents, Alkylating/administration & dosage/pharmacokinetics/therapeutic useBlood Specimen CollectionBusulfan/administration & dosage/pharmacokinetics/therapeutic useChildChild, PreschoolChromatography, High Pressure LiquidDisease-Free SurvivalDose-Response Relationship, DrugDrug Monitoring/methodsFemaleGraft vs Host DiseaseHematopoietic Stem Cell Transplantation/methodsHumansInfantInfusions, IntravenousKaplan-Meier EstimateMaleMultivariate AnalysisProportional Hazards ModelsProspective StudiesSurvival RateTime FactorsTransplantation Conditioning/methodsTreatment OutcomeYoung Adult
Identifiers
PMID: 24061446
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Research group Plateforme d'oncologie et d'hématologie pédiatrique (907)
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ANSARI DJABERI, Marc Georges et al. Association between busulfan exposure and outcome in children receiving intravenous busulfan before hematopoietic stem cell transplantation. In: Therapeutic Drug Monitoring, 2014, vol. 36, n° 1, p. 93-9. https://archive-ouverte.unige.ch/unige:55244

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Deposited on : 2015-04-08

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