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Title

STARTS-2: long-term survival with oral sildenafil monotherapy in treatment-naive pediatric pulmonary arterial hypertension

Authors
Barst, Robyn J
Pulido, Tomas
Layton, Gary
Konourina, Irina
Zhang, Min
Ivy, D Dunbar
Published in Circulation. 2014, vol. 129, no. 19, p. 1914-23
Abstract The double-blind, placebo-controlled Sildenafil in Treatment-Naive Children, Aged 1 to 17 Years, With Pulmonary Arterial Hypertension (STARTS-1) study assessed sildenafil in pediatric patients with pulmonary arterial hypertension; improved hemodynamics and exercise capacity occurred in medium- and high-dose groups. STARTS-2 was the extension study.
Keywords Administration, OralAdolescentChildChild, PreschoolDose-Response Relationship, DrugDouble-Blind MethodExercise Tolerance/drug effects/physiologyFamilial Primary Pulmonary HypertensionFemaleHemodynamics/drug effects/physiologyHumansHypertension, Pulmonary/drug therapy/mortality/physiopathologyInfantKaplan-Meier EstimateMalePiperazines/administration & dosagePurines/administration & dosageRegression AnalysisSulfones/administration & dosageSurvival RateTime FactorsTreatment OutcomeVasodilator Agents/administration & dosage
Identifiers
PMID: 24637559
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Structures
Research group L'hypertension pulmonaire (pédiatrie) (228)
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(ISO format)
BARST, Robyn J et al. STARTS-2: long-term survival with oral sildenafil monotherapy in treatment-naive pediatric pulmonary arterial hypertension. In: Circulation, 2014, vol. 129, n° 19, p. 1914-23. https://archive-ouverte.unige.ch/unige:55241

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Deposited on : 2015-04-08

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