STARTS-2: long-term survival with oral sildenafil monotherapy in treatment-naive pediatric pulmonary arterial hypertension

Barst, Robyn J; Beghetti, Maurice; Pulido, Tomas; Layton, Gary; Konourina, Irina; Zhang, Min; Ivy, D Dunbar

doi:10.1161/CIRCULATIONAHA.113.005698

Scientific article

English

STARTS-2: long-term survival with oral sildenafil monotherapy in treatment-naive pediatric pulmonary arterial hypertension

ContributorsBarst, Robyn J; Beghetti, Maurice; Pulido, Tomas; Layton, Gary; Konourina, Irina; Zhang, Min; Ivy, D Dunbar

Published inCirculation, vol. 129, no. 19, p. 1914-1923

Publication date2014

Abstract

The double-blind, placebo-controlled Sildenafil in Treatment-Naive Children, Aged 1 to 17 Years, With Pulmonary Arterial Hypertension (STARTS-1) study assessed sildenafil in pediatric patients with pulmonary arterial hypertension; improved hemodynamics and exercise capacity occurred in medium- and high-dose groups. STARTS-2 was the extension study.

Keywords

Administration, Oral
Adolescent
Child
Child, Preschool
Dose-Response Relationship, Drug
Double-Blind Method
Exercise Tolerance/drug effects/physiology
Familial Primary Pulmonary Hypertension
Female
Hemodynamics/drug effects/physiology
Humans
Hypertension, Pulmonary/drug therapy/mortality/physiopathology
Infant
Kaplan-Meier Estimate
Male
Piperazines/administration & dosage
Purines/administration & dosage
Regression Analysis
Sulfones/administration & dosage
Survival Rate
Time Factors
Treatment Outcome
Vasodilator Agents/administration & dosage

Affiliation

Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

Research group

L'hypertension pulmonaire (pédiatrie) (228)

Citation (ISO format)

BARST, Robyn J et al. STARTS-2: long-term survival with oral sildenafil monotherapy in treatment-naive pediatric pulmonary arterial hypertension. In: Circulation, 2014, vol. 129, n° 19, p. 1914–1923. doi: 10.1161/CIRCULATIONAHA.113.005698

Article (Published version)

Identifiers

PID : unige:55241
DOI : 10.1161/CIRCULATIONAHA.113.005698
PMID : 24637559

ISSN of the journal0009-7322

553views

0downloads

Creation03/16/2015 2:05:00 PM

First validation03/16/2015 2:05:00 PM

Update time03/14/2023 11:08:34 PM

Status update03/14/2023 11:08:34 PM

Last indexation01/16/2024 5:38:40 PM

Archive ouverte UNIGE

STARTS-2: long-term survival with oral sildenafil monotherapy in treatment-naive pediatric pulmonary arterial hypertension

Technical informations