UNIGE document Scientific Article - Review
previous document  unige:55235  next document
add to browser collection
Title

Prédispositions génétiques dans l'allergie médicamenteuse : importance du HLA

Authors
Published in Revue médicale suisse. 2014, vol. 10, no. 426, p. 864-8
Abstract The pathophysiology of drug allergy is complex and relies on the interaction between the drug and the immune system in combination with environmental factors, in particular viruses. Genetic predisposition plays an important role in drug allergy. Recent publications have shown the importance of HLA genes, particularly in the delayed hypersensitivity reactions. In fact, particular HLA alleles were identified as risk factors in the development of severe allergic reactions to certain drugs, identifying people at risk of hypersensitivity before initiation of specific treatment. In the future, identification of other alleles in HLA genes will improve patients care by preventing hypersensitivity reactions associated with significant morbidity and mortality.
Keywords AllelesDrug Hypersensitivity/etiology/genetics/immunologyGenetic Predisposition to DiseaseHLA Antigens/geneticsHumansHypersensitivity, Delayed/chemically induced/genetics/immunologyRisk Factors
Identifiers
PMID: 24834645
Full text
Structures
Research group Pathogenèse et traitement des allergies alimentaires (191)
Citation
(ISO format)
BERGMANN, Marcel, VILLARD, Jean, CAUBET, Jean-Christoph Roger J-P. Prédispositions génétiques dans l'allergie médicamenteuse : importance du HLA. In: Revue médicale suisse, 2014, vol. 10, n° 426, p. 864-8. https://archive-ouverte.unige.ch/unige:55235

112 hits

0 download

Update

Deposited on : 2015-04-08

Export document
Format :
Citation style :