Use of corticosteroids after hepatoportoenterostomy for bile drainage in infants with biliary atresia: the START randomized clinical trial

Bezerra, Jorge A; Spino, Cathie; Magee, John C; Shneider, Benjamin L; Rosenthal, Philip; Wang, Kasper S; Erlichman, Jessi; Haber, Barbara; Hertel, Paula M; Karpen, Saul J; Kerkar, Nanda; Loomes, Kathleen M; Molleston, Jean P; Murray, Karen F; Romero, Rene; Schwarz, Kathleen B; Shepherd, Ross; Suchy, Frederick J; Turmelle, Yumirle P; Whitington, Peter F; Moore, Jeffrey; Sherker, Averell H; Robuck, Patricia R; Sokol, Ronald J

doi:10.1001/jama.2014.2623

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Title		Use of corticosteroids after hepatoportoenterostomy for bile drainage in infants with biliary atresia: the START randomized clinical trial
Authors		Bezerra, Jorge A Spino, Cathie Magee, John C Shneider, Benjamin L Rosenthal, Philip Wang, Kasper S Erlichman, Jessi Haber, Barbara Hertel, Paula M Karpen, Saul J Kerkar, Nanda Loomes, Kathleen M Molleston, Jean P Murray, Karen F Romero, Rene Schwarz, Kathleen B Shepherd, Ross Suchy, Frederick J Turmelle, Yumirle P Whitington, Peter F Moore, Jeffrey Sherker, Averell H Robuck, Patricia R Sokol, Ronald J show all authors [1 - 24]
Collaboration		Childhood Liver Disease Research and Education Network (ChiLDREN). With : Mclin, Valérie Anne
Published in		JAMA (Journal of the American Medical Association). 2014, vol. 311, no. 17, p. 1750-9
Abstract		Biliary atresia is the most common cause of end-stage liver disease in children. Controversy exists as to whether use of steroids after hepatoportoenterostomy improves clinical outcome.
Keywords		Administration, Oral — Adrenal Cortex Hormones/administration & dosage/adverse effects — Biliary Atresia/drug therapy/surgery — Bilirubin/blood — Double-Blind Method — Drainage/methods — Female — Humans — Infant — Infusions, Intravenous — Male — Methylprednisolone/administration & dosage/adverse effects — Portoenterostomy, Hepatic — Prednisolone/administration & dosage/adverse effects — Survival Analysis — Treatment Outcome
Identifiers		DOI: 10.1001/jama.2014.2623 PMID: 24794368
Full text		Article (Published version) (386 Kb) - Free access
Structures		Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique
Research group		Développement du tube digestif chez les vertébrés (900)
Citation (ISO format)		BEZERRA, Jorge A et al. Use of corticosteroids after hepatoportoenterostomy for bile drainage in infants with biliary atresia: the START randomized clinical trial. In: JAMA (Journal of the American Medical Association), 2014, vol. 311, n° 17, p. 1750-9. doi: 10.1001/jama.2014.2623 https://archive-ouverte.unige.ch/unige:55234