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Potential non-T cells source of interleukin-4 in food allergy

Masilamani, Madhan
Rivers, Neisha A
Mayer, Lloyd
Sampson, Hugh A
Published in Pediatric Allergy and Immunology. 2014, vol. 25, no. 3, p. 243-9
Abstract Recently, a study from the Consortium of Food Allergy Research (CoFAR) showed that allergen-induced IL-4 expression in CD25(+) mononuclear cells was increased in allergic patients. However, they did not find the expected increase in GATA-3 expression, suggesting that allergen-induced IL-4 might not be of T-cell origin. We sought to determine whether other cell types were responsible for the increased IL-4 expression in the CD25(+) cell population.
Keywords AdolescentAdultAntigen PresentationAntigens, CD63/analysisBasophils/immunologyChildChild, PreschoolFemaleFood Hypersensitivity/immunologyHumansInfantInterleukin-2 Receptor alpha Subunit/analysisInterleukin-4/biosynthesisMale
PMID: 24576111
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Article (Published version) (301 Kb) - public document Free access
Research group Pathogenèse et traitement des allergies alimentaires (191)
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CAUBET, Jean-Christoph Roger J-P et al. Potential non-T cells source of interleukin-4 in food allergy. In: Pediatric Allergy and Immunology, 2014, vol. 25, n° 3, p. 243-9. doi: 10.1111/pai.12207 https://archive-ouverte.unige.ch/unige:55196

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Deposited on : 2015-04-07

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