Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial

Douillard, J Y; Cunningham, D; Roth, Arnaud; Navarro, M; James, R D; Karasek, P; Jandik, P; Iveson, T; Carmichael, J; Alakl, M; Gruia, G; Awad, L; Rougier, P

Scientific article

English

Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial

ContributorsDouillard, J Y; Cunningham, D; Roth, Arnaud; Navarro, M; James, R D; Karasek, P; Jandik, P; Iveson, T; Carmichael, J; Alakl, M; Gruia, G; Awad, L; Rougier, P

Published inLancet, vol. 355, no. 9209, p. 1041-1047

Publication date2000

Abstract

Irinotecan is active against colorectal cancer in patients whose disease is refractory to fluorouracil. We investigated the efficacy of these two agents combined for first-line treatment of metastatic colorectal cancer.

Keywords

Adenocarcinoma/drug therapy/mortality/pathology
Adult
Aged
Antineoplastic Agents, Phytogenic/administration & dosage/adverse effects
Antineoplastic Combined Chemotherapy Protocols/adverse effects/therapeutic use
Camptothecin/administration & dosage/adverse effects/analogs & derivatives
Colorectal Neoplasms/drug therapy/mortality/pathology
Female
Fluorouracil/administration & dosage/adverse effects
Humans
Leucovorin/administration & dosage/adverse effects
Male
Middle Aged
Neoplasm Staging
Quality of Life
Survival Rate

Affiliation entities

Research groups

Groupe Roth Arnaud (oncologie) (285)

Citation (ISO format)

DOUILLARD, J Y et al. Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial. In: Lancet, 2000, vol. 355, n° 9209, p. 1041–1047.

Article (Published version)

Identifiers

PID : unige:55094
PMID : 10744089

Additional URL for this publicationhttp://www.sciencedirect.com/science/article/pii/S0140673600020341#

Journal ISSN0140-6736

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Creation01/04/2015 10:31:00

First validation01/04/2015 10:31:00

Update time14/03/2023 23:06:54

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Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial

Irinotecan is active against colorectal cancer in patients whose disease is refractory to fluorouracil. We investigated the efficacy of these two agents combined for first-line treatment of metastatic colorectal cancer.

Technical informations