Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial
ContributorsDouillard, J Y; Cunningham, D; Roth, Arnaud; Navarro, M; James, R D; Karasek, P; Jandik, P; Iveson, T; Carmichael, J; Alakl, M; Gruia, G; Awad, L; Rougier, P
Published inLancet, vol. 355, no. 9209, p. 1041-1047
Publication date2000
Abstract
Keywords
- Adenocarcinoma/drug therapy/mortality/pathology
- Adult
- Aged
- Antineoplastic Agents, Phytogenic/administration & dosage/adverse effects
- Antineoplastic Combined Chemotherapy Protocols/adverse effects/therapeutic use
- Camptothecin/administration & dosage/adverse effects/analogs & derivatives
- Colorectal Neoplasms/drug therapy/mortality/pathology
- Female
- Fluorouracil/administration & dosage/adverse effects
- Humans
- Leucovorin/administration & dosage/adverse effects
- Male
- Middle Aged
- Neoplasm Staging
- Quality of Life
- Survival Rate
Research groups
Citation (ISO format)
DOUILLARD, J Y et al. Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial. In: Lancet, 2000, vol. 355, n° 9209, p. 1041–1047. doi: 10.1016/s0140-6736(00)02034-1
Main files (1)
Article (Published version)
Identifiers
- PID : unige:55094
- DOI : 10.1016/s0140-6736(00)02034-1
- PMID : 10744089
Additional URL for this publicationhttp://www.sciencedirect.com/science/article/pii/S0140673600020341#
Journal ISSN0140-6736
