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Title

Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial

Authors
Douillard, J Y
Cunningham, D
Navarro, M
James, R D
Karasek, P
Jandik, P
Iveson, T
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Published in The Lancet. 2000, vol. 355, no. 9209, p. 1041-7
Abstract Irinotecan is active against colorectal cancer in patients whose disease is refractory to fluorouracil. We investigated the efficacy of these two agents combined for first-line treatment of metastatic colorectal cancer.
Keywords Adenocarcinoma/drug therapy/mortality/pathologyAdultAgedAntineoplastic Agents, Phytogenic/administration & dosage/adverse effectsAntineoplastic Combined Chemotherapy Protocols/adverse effects/therapeutic useCamptothecin/administration & dosage/adverse effects/analogs & derivativesColorectal Neoplasms/drug therapy/mortality/pathologyFemaleFluorouracil/administration & dosage/adverse effectsHumansLeucovorin/administration & dosage/adverse effectsMaleMiddle AgedNeoplasm StagingQuality of LifeSurvival Rate
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PMID: 10744089
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Research group Groupe Roth Arnaud (oncologie) (285)
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DOUILLARD, J Y et al. Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial. In: The Lancet, 2000, vol. 355, n° 9209, p. 1041-7. https://archive-ouverte.unige.ch/unige:55094

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Deposited on : 2015-04-02

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