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Title

Reduced IFNλ4 activity is associated with improved HCV clearance and reduced expression of interferon-stimulated genes

Authors
Terczyńska-Dyla, Ewa
Duong, Francois H T
Krol, Ilona
Jørgensen, Sanne
Collinet, Emilie
Kutalik, Zoltán
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Published in Nature Communications. 2014, vol. 5, p. 5699
Abstract Hepatitis C virus (HCV) infections are the major cause of chronic liver disease, cirrhosis and hepatocellular carcinoma worldwide. Both spontaneous and treatment-induced clearance of HCV depend on genetic variation within the interferon-lambda locus, but until now no clear causal relationship has been established. Here we demonstrate that an amino-acid substitution in the IFNλ4 protein changing a proline at position 70 to a serine (P70S) substantially alters its antiviral activity. Patients harbouring the impaired IFNλ4-S70 variant display lower interferon-stimulated gene (ISG) expression levels, better treatment response rates and better spontaneous clearance rates, compared with patients coding for the fully active IFNλ4-P70 variant. Altogether, these data provide evidence supporting a role for the active IFNλ4 protein as the driver of high hepatic ISG expression as well as the cause of poor HCV clearance.
Identifiers
PMID: 25534433
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Structures
Research groups Etudes et traitement de l'hépatite C et B (554)
Groupe Laurent Kaiser (virologie clinique) (668)
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TERCZYŃSKA-DYLA, Ewa et al. Reduced IFNλ4 activity is associated with improved HCV clearance and reduced expression of interferon-stimulated genes. In: Nature Communications, 2014, vol. 5, p. 5699. https://archive-ouverte.unige.ch/unige:54994

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Deposited on : 2015-03-31

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