UNIGE document Scientific Article - Review
previous document  unige:54988  next document
add to browser collection
Title

Antibiotic allergies in children and adults: from clinical symptoms to skin testing diagnosis

Authors
Romano, Antonino
Published in Journal of Allergy and Clinical Immunology: In Practice. 2014, vol. 2, no. 1, p. 3-12
Abstract Hypersensitivity reactions to β-lactam and non-β-lactam antibiotics are commonly reported. They can be classified as immediate or nonimmediate according to the time interval between the last drug administration and their onset. Immediate reactions occur within 1 hour after the last drug administration and are manifested clinically by urticaria and/or angioedema, rhinitis, bronchospasm, and anaphylactic shock; they may be mediated by specific IgE-antibodies. Nonimmediate reactions occur more than 1 hour after the last drug administration. The most common manifestations are maculopapular exanthems; specific T lymphocytes may be involved in this type of manifestation. The diagnostic evaluation of hypersensitivity reactions to antibiotics is usually complex. The patient's history is fundamental; the allergic examination is based mainly on in vivo tests selected on the basis of the clinical features and the type of reaction, immediate or nonimmediate. Immediate reactions can be assessed by immediate-reading skin tests and, in selected cases, drug provocation tests. Nonimmediate reactions can be assessed by delayed-reading skin tests, patch tests, and drug provocation tests. However, skin tests have been well validated mainly for β-lactams but less for other classes of antibiotics.
Keywords AdultAge FactorsAnti-Bacterial Agents/adverse effectsChildDrug Hypersensitivity/diagnosis/immunology/therapyHumansHypersensitivity, Delayed/chemically induced/diagnosis/immunologyHypersensitivity, Immediate/chemically induced/diagnosis/immunology/therapyPredictive Value of TestsPrognosisRisk FactorsSkin TestsTime Factors
Identifiers
PMID: 24565763
Full text
Article (Published version) (512 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group Pathogenèse et traitement des allergies alimentaires (191)
Citation
(ISO format)
ROMANO, Antonino, CAUBET, Jean-Christoph Roger J-P. Antibiotic allergies in children and adults: from clinical symptoms to skin testing diagnosis. In: Journal of Allergy and Clinical Immunology: In Practice, 2014, vol. 2, n° 1, p. 3-12. https://archive-ouverte.unige.ch/unige:54988

187 hits

0 download

Update

Deposited on : 2015-03-31

Export document
Format :
Citation style :