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Insulin resistance, non-alcoholic fatty liver disease and hepatitis C virus infection

Published in Reviews on Recent Clinical Trials. 2014, vol. 9, no. 3, p. 204-9
Abstract Due to their high prevalence, non-alcoholic fatty liver disease (NAFLD), insulin resistance (IR) and hepatitis C virus (HCV) infection are bound to cohabit. However, the relationship between these 3 entities is complex and multilayered. HCV, particularly genotype 3, may induce a "viral" steatosis, morphologically indistinguishable from the steatosis of NAFLD but with different implications and prognosis. On the other hand, epidemiological and experimental data show that patients with HCV have a higher risk of developing IR and, in susceptible individuals, type 2 diabetes (T2D). In patients with HCV, T2D increases fibrosis progression rate, increases the incidence of HCC, worsens liver-related outcomes and worsens response to interferon-α based therapy. We conclude by discussing a possible increased incidence of cardiovascular events in HCV patients.
PMID: 25514907
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Research group Etudes et traitement de l'hépatite C et B (554)
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GOOSSENS, Nicolas, NEGRO, Francesco. Insulin resistance, non-alcoholic fatty liver disease and hepatitis C virus infection. In: Reviews on Recent Clinical Trials, 2014, vol. 9, n° 3, p. 204-9. doi: 10.2174/1574887109666141216101939 https://archive-ouverte.unige.ch/unige:54984

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Deposited on : 2015-03-31

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