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Title

Coagulation and thrombotic disorders associated with pig organ and hematopoietic cell transplantation in nonhuman primates

Authors
Basker, M
Alwayn, I P
Goepfert, C
Kitamura, H
Kawai, T
Gojo, S
Kozlowski, T
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Published in Transplantation. 2000, vol. 70, no. 9, p. 1323-31
Abstract Efforts to achieve tolerance to transplanted pig organs in nonhuman primates by the induction of a state of mixed hematopoietic chimerism have been associated with disorders of coagulation and thrombosis. Activation of recipient vascular endothelium and platelets by porcine hematopoietic cells and/or activation of donor organ vascular endothelium and/or molecular differences between the species may play roles. Irradiation or drug therapy could possibly potentiate endothelial cell activation and/or injury.
Keywords AnimalsBlood Coagulation Disorders/complications/etiologyFemaleGraft Rejection/complications/etiologyHematopoietic Stem Cell TransplantationHumansMacaca fascicularisMaleOrgan Transplantation/physiologyPapioSwineThrombosis/complications/etiologyTransplantation ChimeraTransplantation Immunology/immunologyTransplantation ToleranceTransplantation, Heterologous
Identifiers
PMID: 11087147
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Structures
Research group Cultures cellulaires et transplantations (519)
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(ISO format)
BUEHLER, Leo Hans et al. Coagulation and thrombotic disorders associated with pig organ and hematopoietic cell transplantation in nonhuman primates. In: Transplantation, 2000, vol. 70, n° 9, p. 1323-31. https://archive-ouverte.unige.ch/unige:54981

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Deposited on : 2015-03-31

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