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Title

Target Temperature Management after out-of-hospital cardiac arrest--a randomized, parallel-group, assessor-blinded clinical trial--rationale and design

Authors
Nielsen, Niklas
Wetterslev, Jørn
Published in American Heart Journal. 2012, vol. 163, no. 4, p. 541-548
Abstract Experimental animal studies and previous randomized trials suggest an improvement in mortality and neurologic function with induced hypothermia after cardiac arrest. International guidelines advocate the use of a target temperature management of 32°C to 34°C for 12 to 24 hours after resuscitation from out-of-hospital cardiac arrest. A systematic review indicates that the evidence for recommending this intervention is inconclusive, and the GRADE level of evidence is low. Previous trials were small, with high risk of bias, evaluated select populations, and did not treat hyperthermia in the control groups. The optimal target temperature management strategy is not known.
Keywords Body TemperatureHumansMulticenter Studies as TopicOut-of-Hospital Cardiac Arrest/therapyQuality of LifeRandomized Controlled Trials as TopicResearch DesignTreatment Outcome
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PMID: 22520518
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Research group Groupe Gasche Yvan (Soins intensifs) (501)
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NIELSEN, Niklas, WETTERSLEV, Jørn, GASCHE, Yvan. Target Temperature Management after out-of-hospital cardiac arrest--a randomized, parallel-group, assessor-blinded clinical trial--rationale and design. In: American Heart Journal, 2012, vol. 163, n° 4, p. 541-548. https://archive-ouverte.unige.ch/unige:54947

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Deposited on : 2015-03-31

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