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The exceptional and far-flung manifestations of heart failure in Eisenmenger syndrome

Opotowsky, Alexander R
Landzberg, Michael J
Published in Heart failure clinics. 2014, vol. 10, no. 1, p. 91-104
Abstract Dramatic advances in the diagnosis and treatment of congenital heart disease (CHD), the most common inborn defect, has resulted in a growing population of adults with CHD. Eisenmenger syndrome (ES) represents the extreme form of pulmonary arterial hypertension associated with CHD, characterized by markedly increased pulmonary vascular resistance with consequently reversed or bidirectional shunting. While ES is a direct consequence of a heart defect, it is a fundamentally multisystem syndrome with wide-ranging clinical manifestations. The introduction of targeted pulmonary hypertension therapies aimed has subtly shifted clinical focus from preventing iatrogenic and other adverse events toward cautious therapeutic activism.
Keywords AdultAntihypertensive Agents/therapeutic useCardiac Surgical Procedures/adverse effects/methodsClassificationDisease ManagementEisenmenger Complex/complications/diagnosis/epidemiology/physiopathology/surgeryEuropeExercise Tolerance/drug effectsFamilial Primary Pulmonary HypertensionHeart Failure/diagnosis/etiology/physiopathology/therapyHumansHypertension, Pulmonary/classification/diagnosis/etiology/physiopathology/therapyIron/therapeutic useMultiple Organ Failure/etiology/physiopathology/prevention & controlOxygen Inhalation Therapy/methodsPractice Guidelines as TopicPrevalencePrognosisPulmonary Circulation/drug effectsTrace Elements/therapeutic use
PMID: 24275297
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Research group L'hypertension pulmonaire (pédiatrie) (228)
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OPOTOWSKY, Alexander R, LANDZBERG, Michael J, BEGHETTI, Maurice. The exceptional and far-flung manifestations of heart failure in Eisenmenger syndrome. In: Heart failure clinics, 2014, vol. 10, n° 1, p. 91-104. doi: 10.1016/j.hfc.2013.09.005 https://archive-ouverte.unige.ch/unige:54931

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Deposited on : 2015-03-30

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