Matrix metalloproteinase-9 concentration in the cerebral extracellular fluid of patients during the acute phase of aneurysmal subarachnoid hemorrhage

Sarrafzadeh-Khorassani, Asita Simone; Copin, Jean-Christophe; Bengualid, Daniel Jiménez; Turck, Natacha; Vajkoczy, Peter; Bijlenga, Philippe Alexandre Pierre; Schaller, Karl Lothard; Gasche, Yvan

doi:10.1179/1743132812Y.0000000018

Scientific article

English

Matrix metalloproteinase-9 concentration in the cerebral extracellular fluid of patients during the acute phase of aneurysmal subarachnoid hemorrhage

ContributorsSarrafzadeh-Khorassani, Asita Simone; Copin, Jean-Christophe; Bengualid, Daniel Jiménez; Turck, Natacha; Vajkoczy, Peter; Bijlenga, Philippe Alexandre Pierre

; Schaller, Karl Lothard; Gasche, Yvan

Published inNeurological research, vol. 34, no. 5, p. 455-461

Publication date2012

Abstract

The pathogenesis of delayed cerebral ischemia (DCI) in aneurysmal subarachnoid hemorrhage (aSAH) is multi-factorial and not completely elucidated. Matrix metalloproteinase-9 (MMP-9) might participate in wall remodeling leading to luminal narrowing. The authors investigated MMP-9 concentration in brain extracellular fluid of aSAH patients and assessed whether this enzyme could have a predictive value for the risk of DCI.

Keywords

Adult
Aged
Cerebral Cortex/pathology/radiography
Extracellular Fluid/enzymology
Female
Humans
Male
Matrix Metalloproteinase 9/metabolism
Microdialysis
Middle Aged
Prospective Studies
ROC Curve
Retrospective Studies
Subarachnoid Hemorrhage/enzymology/pathology/radiography
Tomography, X-Ray Computed

Affiliation entities

Research groups

Citation (ISO format)

SARRAFZADEH-KHORASSANI, Asita Simone et al. Matrix metalloproteinase-9 concentration in the cerebral extracellular fluid of patients during the acute phase of aneurysmal subarachnoid hemorrhage. In: Neurological research, 2012, vol. 34, n° 5, p. 455–461. doi: 10.1179/1743132812Y.0000000018

Article (Published version)

Identifiers

PID : unige:54873
DOI : 10.1179/1743132812Y.0000000018
PMID : 22449315

Journal ISSN0161-6412

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Matrix metalloproteinase-9 concentration in the cerebral extracellular fluid of patients during the acute phase of aneurysmal subarachnoid hemorrhage

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