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Title

Importance of junctional adhesion molecule-C for neointimal hyperplasia and monocyte recruitment in atherosclerosis-prone mice-brief report

Authors
Shagdarsuren, Erdenechimeg
Djalali-Talab, Yassin
Bidzhekov, Kiril
Liehn, Elisa A.
Weber, Christian
Zernecke, Alma
Published in Arteriosclerosis, Thrombosis, and Vascular Biology. 2009, vol. 29, no. 8, p. 1161-3
Abstract OBJECTIVE: Although junctional adhesion molecule (JAM)-C has been implicated in the control of inflammatory leukocyte recruitment, its role in neointima formation after arterial injury has not been elucidated. METHODS AND RESULTS: In apolipoprotein E-deficient (Apoe(-/-)) mice fed an atherogenic diet, antibody blockade of JAM-C significantly reduced neointimal hyperplasia after wire injury of carotid arteries without altering medial area and decreased neointimal macrophage but not smooth muscle cell (SMC) content. An increased expression of JAM-C was detected in colocalization with luminal SMCs 1 day after injury and neointimal SMCs after 3 weeks. Blocking JAM-C inhibited monocytic cell arrest and leukocyte adhesion to carotid arteries perfused ex vivo and in vivo. Furthermore, monocyte adhesion to activated coronary artery SMCs under flow conditions in vitro was diminished by blocking JAM-C. CONCLUSIONS: Our data provide the first evidence for a crucial role of JAM-C in accelerated lesion formation and leukocyte recruitment in atherosclerosis-prone mice.
Keywords AnimalsAtherosclerosis/metabolism/pathologyCarotid Arteries/metabolism/pathologyCell AdhesionCell Adhesion Molecules/metabolismDisease Models, AnimalFlow CytometryHyperplasiaImmunoglobulins/metabolismMiceMonocytes/pathologyTunica Intima/metabolism/pathology
Identifiers
PMID: 19520977
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Other version: http://atvb.ahajournals.org/cgi/content/full/29/8/1161
Structures
Research group Molécules d'adhésion et processus de migration cellulaire (167)
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SHAGDARSUREN, Erdenechimeg et al. Importance of junctional adhesion molecule-C for neointimal hyperplasia and monocyte recruitment in atherosclerosis-prone mice-brief report. In: Arteriosclerosis, Thrombosis, and Vascular Biology, 2009, vol. 29, n° 8, p. 1161-3. https://archive-ouverte.unige.ch/unige:5434

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Deposited on : 2010-03-16

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