Scientific article

Prefrontal plasticity and stress inoculation-induced resilience

Published inDevelopmental neuroscience, vol. 31, no. 4, p. 293-299
Publication date2009

Coping with mild early life stress tends to make subsequent coping efforts more effective and therefore more likely to be used as a means of arousal regulation and resilience. Here we show that this developmental learning-like process of stress inoculation increases ventromedial prefrontal cortical volumes in peripubertal monkeys. Larger volumes do not reflect increased cortical thickness but instead represent surface area expansion of ventromedial prefrontal cortex. Expansion of ventromedial prefrontal cortex coincides with increased white matter myelination inferred from diffusion tensor magnetic resonance imaging. These findings suggest that the process of coping with early life stress increases prefrontal myelination and expands a region of cortex that broadly controls arousal regulation and resilience.

  • Animals
  • Anxiety, Separation/physiopathology/psychology
  • Female
  • Humans
  • Male
  • Neuronal Plasticity/physiology
  • Prefrontal Cortex/anatomy & histology/physiology
  • Random Allocation
  • Saimiri
  • Stress, Psychological/physiopathology/psychology
Citation (ISO format)
KATZ, Maor et al. Prefrontal plasticity and stress inoculation-induced resilience. In: Developmental neuroscience, 2009, vol. 31, n° 4, p. 293–299. doi: 10.1159/000216540
Main files (1)
Article (Published version)
ISSN of the journal0378-5866

Technical informations

Creation03/16/2010 9:52:00 AM
First validation03/16/2010 9:52:00 AM
Update time03/14/2023 3:25:02 PM
Status update03/14/2023 3:25:02 PM
Last indexation10/18/2023 8:36:23 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack