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Prefrontal plasticity and stress inoculation-induced resilience

Katz, Maor
Liu, Chunlei
Parker, Karen J.
Epps, Averi
Buckmaster, Christine L.
Bammer, Roland
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Published in Developmental neuroscience. 2009, vol. 31, no. 4, p. 293-9
Abstract Coping with mild early life stress tends to make subsequent coping efforts more effective and therefore more likely to be used as a means of arousal regulation and resilience. Here we show that this developmental learning-like process of stress inoculation increases ventromedial prefrontal cortical volumes in peripubertal monkeys. Larger volumes do not reflect increased cortical thickness but instead represent surface area expansion of ventromedial prefrontal cortex. Expansion of ventromedial prefrontal cortex coincides with increased white matter myelination inferred from diffusion tensor magnetic resonance imaging. These findings suggest that the process of coping with early life stress increases prefrontal myelination and expands a region of cortex that broadly controls arousal regulation and resilience.
Keywords AnimalsAnxiety, Separation/physiopathology/psychologyFemaleHumansMaleNeuronal Plasticity/physiologyPrefrontal Cortex/anatomy & histology/physiologyRandom AllocationSaimiriStress, Psychological/physiopathology/psychology
PMID: 19546566
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Research group Laboratoire d'imagerie et de psychopathologie développementale (693)
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KATZ, Maor et al. Prefrontal plasticity and stress inoculation-induced resilience. In: Developmental neuroscience, 2009, vol. 31, n° 4, p. 293-9. doi: 10.1159/000216540 https://archive-ouverte.unige.ch/unige:5423

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Deposited on : 2010-03-16

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