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Experience-dependent structural synaptic plasticity in the mammalian brain

Svoboda, Karel
Published in Nature reviews. Neuroscience. 2009, vol. 10, no. 9, p. 647-658
Abstract Synaptic plasticity in adult neural circuits may involve the strengthening or weakening of existing synapses as well as structural plasticity, including synapse formation and elimination. Indeed, long-term in vivo imaging studies are beginning to reveal the structural dynamics of neocortical neurons in the normal and injured adult brain. Although the overall cell-specific morphology of axons and dendrites, as well as of a subpopulation of small synaptic structures, are remarkably stable, there is increasing evidence that experience-dependent plasticity of specific circuits in the somatosensory and visual cortex involves cell type-specific structural plasticity: some boutons and dendritic spines appear and disappear, accompanied by synapse formation and elimination, respectively. This Review focuses on recent evidence for such structural forms of synaptic plasticity in the mammalian cortex and outlines open questions.
Keywords AnimalsBrain/cytology/growth & development/physiologyHumansNerve Net/cytology/growth & development/physiologyNeurogenesis/physiologyNeuronal Plasticity/physiologySynapses/physiology
PMID: 19693029
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Other version: http://www.nature.com/nrn/journal/v10/n9/abs/nrn2699.html
Research group Les circuits neuronaux dans le néocortex des mammifères (855)
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HOLTMAAT, Anthony, SVOBODA, Karel. Experience-dependent structural synaptic plasticity in the mammalian brain. In: Nature reviews. Neuroscience, 2009, vol. 10, n° 9, p. 647-658. doi: 10.1038/nrn2699 https://archive-ouverte.unige.ch/unige:5363

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Deposited on : 2010-03-08

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