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Title

Cardiac and pulmonary late effects do not negatively influence performance status and non-relapse mortality of children surviving five yr after autologous hematopoietic cell transplantation

Authors
Uderzo, Cornelio
Pillon, Marta
Tridello, Gloria
Dini, Giorgio
Urban, Christian
Corti, Paola
Zintl, Felix
Fagioli, Franca
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Published in Pediatric transplantation. 2009, vol. 13, no. 6, p. 719-24
Abstract The current prospective study dealt with clinical outcome associated with pulmonary and cardiac late effects of AuHCT in children with malignancies. We prospectively evaluated 58 children, utilizing pulmonary function tests and cardiac shortening fraction, performed in pre-AuHCT phase and then annually. The overall five-yr survival was 68%. The five-yr cumulative incidence of lung and cardiac function impairment in survivors was 21% in both cases. None of the patients presented with restrictive or obstructive pulmonary pathology at the last follow-up and performance status for all survivors, ranged from 90% to 100%. The cumulative incidence of non-relapse mortality was 12.6% (range 6.3-25.3%), whereas relapse mortality was 19.7% (range 11.6-33.5). In conclusion, our study shows no significant deterioration in post-AuHCT pulmonary and cardiac function and in particular, no negative impact of lung and heart late effects on performance status and non-relapse mortality.
Keywords AdolescentChildChild, PreschoolFemaleHeart/physiologyHematopoietic Stem Cell Transplantation/adverse effects/methodsHumansIncidenceInfantLung/physiologyMalePediatrics/methodsProspective StudiesRespiratory Function TestsTime FactorsTreatment Outcome
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PMID: 18992061
Note Report from the EBMT Paediatric Diseases and Late Effects Working Parties
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UDERZO, Cornelio et al. Cardiac and pulmonary late effects do not negatively influence performance status and non-relapse mortality of children surviving five yr after autologous hematopoietic cell transplantation. In: Pediatric Transplantation, 2009, vol. 13, n° 6, p. 719-24. https://archive-ouverte.unige.ch/unige:5328

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Deposited on : 2010-03-04

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