UNIGE document Scientific Article
previous document  unige:5217  next document
add to browser collection

Young patients with endometrial cancer: how many could be eligible for fertility-sparing treatment?

Navarria, Isabelle
Neyroud-Caspar, Isabelle
Published in Gynecologic Oncology. 2009, vol. 114, no. 3, p. 448-51
Abstract OBJECTIVES: To assess the characteristics of young women with endometrial carcinoma, and evaluate those potentially eligible for conservative therapy. METHODS: We identified women diagnosed with endometrial cancer between 1970 and 2005 at the population-based Geneva Cancer Registry (n=1365). We classified patients into two age groups (< or =45 and >45 years old). Differences in demographic, tumor, diagnostic and treatment characteristics were tested with chi square. Kaplan-Meier analysis was used to calculate survival from endometrial cancer and the log-rank test to analyze differences in survival between the two groups. RESULTS: The young group comprised 44 (3.2%) women and the old group 1321 (96.8%) women. Synchronous ovarian malignancies were found in six patients (14%) in the young group, compared with 23 (2%) in the old group (P<0.001). Tumor stage was also different between the two groups, principally because of more stage II among the young (P=0.012). Histological tumor type, grade and specific endometrial cancer 5-year survival did not significantly differ between the two groups. According to final histopathologic evaluation, eight patients from the young group had FIGO stage IA, grade I disease, i.e. may have been eligible for fertility-sparing treatment, corresponding to an incidence rate of 0.3/100,000. CONCLUSION: No significant difference regarding tumor characteristics and survival between young and older patients was observed, except stage of disease and rate of synchronous ovarian malignancy. Conservative approach is a meaningful quality of life goal for patients with cancer, but only suitable for a limited number of patients.
Keywords AdultAge FactorsEndometrial Neoplasms/pathology/therapyFemaleFertilityFollow-Up StudiesHumansMiddle AgedNeoplasm StagingYoung Adult
PMID: 19560801
Full text
Article (Published version) (132 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Research groups Carcinome mammaire type « basal-like » (656)
Groupe Bouchardy Magnin Christine (Registre genevois des tumeurs) (532)
Groupe Petignat Patrick (933)
(ISO format)
NAVARRIA, Isabelle et al. Young patients with endometrial cancer: how many could be eligible for fertility-sparing treatment?. In: Gynecologic Oncology, 2009, vol. 114, n° 3, p. 448-51. doi: 10.1016/j.ygyno.2009.05.038 https://archive-ouverte.unige.ch/unige:5217

523 hits

0 download


Deposited on : 2010-02-17

Export document
Format :
Citation style :