In vivo methods for the assessment of topical drug bioavailability

Herkenne, Christophe; Alberti, Ingo; Naik, Aarti; Kalia, Yogeshvar; Mathy, François-Xavier; Préat, Véronique; Guy, Richard H.

doi:10.1007/s11095-007-9429-7

Scientific article

English

In vivo methods for the assessment of topical drug bioavailability

Contributors

Herkenne, Christophe; Alberti, Ingo; Naik, Aarti; Kalia, Yogeshvar

; Mathy, François-Xavier; Préat, Véronique; Guy, Richard H.

Published in

Pharmaceutical research, vol. 25, no. 1, p. 87-103

Collection

Open Access - Licence nationale Springer

Publication date

2008

Abstract

This paper reviews some current methods for the in vivo assessment of local cutaneous bioavailability in humans after topical drug application. After an introduction discussing the importance of local drug bioavailability assessment and the limitations of model-based predictions, the focus turns to the relevance of experimental studies. The available techniques are then reviewed in detail, with particular emphasis on the tape stripping and microdialysis methodologies. Other less developed techniques, including the skin biopsy, suction blister, follicle removal and confocal Raman spectroscopy techniques are also described.

UNIGE affiliation entities

Faculté des sciences / Section des sciences pharmaceutiques

Citation (ISO format)

HERKENNE, Christophe et al. In vivo methods for the assessment of topical drug bioavailability. In: Pharmaceutical research, 2008, vol. 25, n° 1, p. 87–103. doi: 10.1007/s11095-007-9429-7

Article (Published version)

OA NATIONAL

Identifiers

PID : unige:5
DOI : 10.1007/s11095-007-9429-7
PMID : 17985216

Journal ISSN

0724-8741

717views

514downloads

Creation

29/10/2008 11:37:27

First validation

29/10/2008 11:37:27

Update

14/03/2023 14:55:04

Status update

14/03/2023 14:55:04

Last indexation

29/10/2024 10:46:43

In vivo methods for the assessment of topical drug bioavailability

Contributors

Published in

Collection

Publication date

Abstract

UNIGE affiliation entities

Citation (ISO format)

Main files (1)

Identifiers

Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation