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In vivo methods for the assessment of topical drug bioavailability

Mathy, François-Xavier
Préat, Véronique
Published in Pharmaceutical research. 2008, vol. 25, no. 1, p. 87-103
Collection Open Access - Licence nationale Springer
Abstract This paper reviews some current methods for the in vivo assessment of local cutaneous bioavailability in humans after topical drug application. After an introduction discussing the importance of local drug bioavailability assessment and the limitations of model-based predictions, the focus turns to the relevance of experimental studies. The available techniques are then reviewed in detail, with particular emphasis on the tape stripping and microdialysis methodologies. Other less developed techniques, including the skin biopsy, suction blister, follicle removal and confocal Raman spectroscopy techniques are also described.
PMID: 17985216
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HERKENNE, Christophe et al. In vivo methods for the assessment of topical drug bioavailability. In: Pharmaceutical research, 2008, vol. 25, n° 1, p. 87-103. doi: 10.1007/s11095-007-9429-7 https://archive-ouverte.unige.ch/unige:5

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Deposited on : 2008-10-29

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