Scientific article
Open access

In vivo methods for the assessment of topical drug bioavailability

Published inPharmaceutical research, vol. 25, no. 1, p. 87-103
  • Open Access - Licence nationale Springer
Publication date2008

This paper reviews some current methods for the in vivo assessment of local cutaneous bioavailability in humans after topical drug application. After an introduction discussing the importance of local drug bioavailability assessment and the limitations of model-based predictions, the focus turns to the relevance of experimental studies. The available techniques are then reviewed in detail, with particular emphasis on the tape stripping and microdialysis methodologies. Other less developed techniques, including the skin biopsy, suction blister, follicle removal and confocal Raman spectroscopy techniques are also described.

Citation (ISO format)
HERKENNE, Christophe et al. In vivo methods for the assessment of topical drug bioavailability. In: Pharmaceutical research, 2008, vol. 25, n° 1, p. 87–103. doi: 10.1007/s11095-007-9429-7
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Article (Published version)
ISSN of the journal0724-8741

Technical informations

Creation10/29/2008 11:37:27 AM
First validation10/29/2008 11:37:27 AM
Update time03/14/2023 2:55:04 PM
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