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Scientific article
Open access
English

In vivo methods for the assessment of topical drug bioavailability

Published inPharmaceutical research, vol. 25, no. 1, p. 87-103
Collection
  • Open Access - Licence nationale Springer
Publication date2008
Abstract

This paper reviews some current methods for the in vivo assessment of local cutaneous bioavailability in humans after topical drug application. After an introduction discussing the importance of local drug bioavailability assessment and the limitations of model-based predictions, the focus turns to the relevance of experimental studies. The available techniques are then reviewed in detail, with particular emphasis on the tape stripping and microdialysis methodologies. Other less developed techniques, including the skin biopsy, suction blister, follicle removal and confocal Raman spectroscopy techniques are also described.

Citation (ISO format)
HERKENNE, Christophe et al. In vivo methods for the assessment of topical drug bioavailability. In: Pharmaceutical research, 2008, vol. 25, n° 1, p. 87–103. doi: 10.1007/s11095-007-9429-7
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Article (Published version)
Identifiers
ISSN of the journal0724-8741
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Technical informations

Creation10/29/2008 11:37:27 AM
First validation10/29/2008 11:37:27 AM
Update time03/14/2023 2:55:04 PM
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