Synthesis of 3-hydroxyoxindoles by Pd-catalysed intramolecular nucleophilic addition of aryl halides to α-ketoamides

Jia, Yi-Xia; Katayev, Dmitry; Kundig, Ernst Peter

doi:10.1039/b917958e

Scientific article

English

Synthesis of 3-hydroxyoxindoles by Pd-catalysed intramolecular nucleophilic addition of aryl halides to α-ketoamides

ContributorsJia, Yi-Xia; Katayev, Dmitry; Kundig, Ernst Peter

Published inChemical communications, vol. 46, no. 1, p. 130-132

Publication date2010

Abstract

Pd/PtBu3-catalysed intramolecular nucleophilic addition of aryl halides to α-ketoamides in the presence of nBuOH and base has been realized with high yields, providing a new, direct, and efficient synthetic strategy to obtain 3-hydroxyoxindoles.

Affiliation

Faculté des sciences / Section de chimie et biochimie / Département de chimie organique

Citation (ISO format)

JIA, Yi-Xia, KATAYEV, Dmitry, KUNDIG, Ernst Peter. Synthesis of 3-hydroxyoxindoles by Pd-catalysed intramolecular nucleophilic addition of aryl halides to α-ketoamides. In: Chemical communications, 2010, vol. 46, n° 1, p. 130–132. doi: 10.1039/b917958e

Article (Published version)

Identifiers

PID : unige:4865
DOI : 10.1039/b917958e

ISSN of the journal1359-7345

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Synthesis of 3-hydroxyoxindoles by Pd-catalysed intramolecular nucleophilic addition of aryl halides to α-ketoamides

Pd/PtBu3-catalysed intramolecular nucleophilic addition of aryl halides to α-ketoamides in the presence of nBuOH and base has been realized with high yields, providing a new, direct, and efficient synthetic strategy to obtain 3-hydroxyoxindoles.

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