Scientific article

Epidural sufentanil during paediatric cardiac surgery: effects on metabolic response and postoperative outcome

Published inPaediatric anaesthesia, vol. 10, no. 6, p. 609-617
Publication date2000

The metabolic and neuroendocrine effects of caudal epidural analgesia were studied during paediatric cardiac surgery. Combined epidural and general anaesthesia (EPI group; n=12) was compared with deep opioid anaesthesia (DOA group; n=12). During anaesthesia and surgery, haemodynamic stability was similar in the two groups. There was no significant difference between groups concerning the metabolic response to surgery but circulating catecholamines were significantly lower in the EPI group during and after surgery. Perioperative release of IL-6 was higher in the EPI group possibly reflecting a longer aortic clamp time. Incidence of postoperative life-threatening dysrhythmias was very low in the two groups. No significant reduction of postoperative mechanical ventilation, intensive care unit or hospital stays was reported with epidural analgesia. The incidence of postoperative infections was higher than expected in the two groups because of the poor properative clinical status of most of the children included in the study.

  • Analgesia, Epidural
  • Analgesics, Opioid
  • Anesthesia, General
  • Blood Glucose/analysis
  • C-Reactive Protein/analysis
  • Cardiac Surgical Procedures
  • Catecholamines/blood
  • Child, Preschool
  • Growth Hormone/blood
  • Heart Defects, Congenital/surgery
  • Hemodynamics
  • Humans
  • Hydrocortisone/blood
  • Infant
  • Interleukin-6/blood
  • Lactates/blood
  • Postoperative Complications
  • Stress, Physiological/blood/etiology/physiopathology
  • Sufentanil
Citation (ISO format)
BICHEL, T et al. Epidural sufentanil during paediatric cardiac surgery: effects on metabolic response and postoperative outcome. In: Paediatric anaesthesia, 2000, vol. 10, n° 6, p. 609–617. doi: 10.1111/j.1460-9592.2000.00557.x
Main files (1)
Article (Published version)
ISSN of the journal1155-5645

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