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Title

Cyclosporine toxicity in renal transplant recipients detected by nailfold capillaroscopy with Na-fluorescein
Authors
Bongard, Olivier
Weimer, Daniel
Lemoine, Robert
Bolle, Jean François
Leski, Michel
Bounameaux, Henri
Published in Kidney International. 2000, vol. 58, no. 6, p. 2559-63
Abstract Cyclosporine represented a major advance in the medical management of patients with organ transplantation, but its use is limited by the frequent occurrence of hypertension and renal toxicity diagnosed by invasive renal biopsy. Renal histology shows a specific arteriolopathy. It was hypothesized that cyclosporine may also induce subclinical microvascular changes in the skin that might be detected noninvasively by a combination of dynamic capillaroscopy [capillary blood cell velocity (CBV)] with and without intravenous Na-fluorescein (NaF) injection and laser Doppler fluxmetry (LDF).
Keywords Adult — Biopsy — Blood Flow Velocity/drug effects — Capillaries/drug effects/physiology — Contrast Media/pharmacokinetics — Cyclosporine/toxicity — Female — Fluorescein/diagnostic use/pharmacokinetics — Graft Rejection/drug therapy/physiopathology/ultrasonography — Humans — Immunosuppressive Agents/toxicity — Kidney/pathology — Kidney Failure, Chronic/surgery — Kidney Transplantation — Laser-Doppler Flowmetry/methods — Male — Middle Aged — Nails/blood supply/ultrasonography — Skin/blood supply/ultrasonography — Skin Temperature
Identifiers
PMID: 11115091
Full text
Article (Published version) (180 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Faculté de médecine / Section de médecine clinique / Département de médecine interne des spécialités
Faculté de médecine / Section de médecine clinique / Département de chirurgie
Research group Groupe Iselin Christophe (urologie) (106)
Citation
(ISO format) 		BONGARD, Olivier et al. Cyclosporine toxicity in renal transplant recipients detected by nailfold capillaroscopy with Na-fluorescein. In: Kidney International, 2000, vol. 58, n° 6, p. 2559-63. https://archive-ouverte.unige.ch/unige:48441

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Deposited on : 2015-03-25

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