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Cyclosporine toxicity in renal transplant recipients detected by nailfold capillaroscopy with Na-fluorescein

Published in Kidney International. 2000, vol. 58, no. 6, p. 2559-63
Abstract Cyclosporine represented a major advance in the medical management of patients with organ transplantation, but its use is limited by the frequent occurrence of hypertension and renal toxicity diagnosed by invasive renal biopsy. Renal histology shows a specific arteriolopathy. It was hypothesized that cyclosporine may also induce subclinical microvascular changes in the skin that might be detected noninvasively by a combination of dynamic capillaroscopy [capillary blood cell velocity (CBV)] with and without intravenous Na-fluorescein (NaF) injection and laser Doppler fluxmetry (LDF).
Keywords AdultBiopsyBlood Flow Velocity/drug effectsCapillaries/drug effects/physiologyContrast Media/pharmacokineticsCyclosporine/toxicityFemaleFluorescein/diagnostic use/pharmacokineticsGraft Rejection/drug therapy/physiopathology/ultrasonographyHumansImmunosuppressive Agents/toxicityKidney/pathologyKidney Failure, Chronic/surgeryKidney TransplantationLaser-Doppler Flowmetry/methodsMaleMiddle AgedNails/blood supply/ultrasonographySkin/blood supply/ultrasonographySkin Temperature
PMID: 11115091
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Research group Groupe Iselin Christophe (urologie) (106)
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BONGARD, Olivier et al. Cyclosporine toxicity in renal transplant recipients detected by nailfold capillaroscopy with Na-fluorescein. In: Kidney International, 2000, vol. 58, n° 6, p. 2559-63. https://archive-ouverte.unige.ch/unige:48441

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Deposited on : 2015-03-25

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