Scientific article

Cyclosporine toxicity in renal transplant recipients detected by nailfold capillaroscopy with Na-fluorescein

Published inKidney international, vol. 58, no. 6, p. 2559-2563
Publication date2000

Cyclosporine represented a major advance in the medical management of patients with organ transplantation, but its use is limited by the frequent occurrence of hypertension and renal toxicity diagnosed by invasive renal biopsy. Renal histology shows a specific arteriolopathy. It was hypothesized that cyclosporine may also induce subclinical microvascular changes in the skin that might be detected noninvasively by a combination of dynamic capillaroscopy [capillary blood cell velocity (CBV)] with and without intravenous Na-fluorescein (NaF) injection and laser Doppler fluxmetry (LDF).

  • Adult
  • Biopsy
  • Blood Flow Velocity/drug effects
  • Capillaries/drug effects/physiology
  • Contrast Media/pharmacokinetics
  • Cyclosporine/toxicity
  • Female
  • Fluorescein/diagnostic use/pharmacokinetics
  • Graft Rejection/drug therapy/physiopathology/ultrasonography
  • Humans
  • Immunosuppressive Agents/toxicity
  • Kidney/pathology
  • Kidney Failure, Chronic/surgery
  • Kidney Transplantation
  • Laser-Doppler Flowmetry/methods
  • Male
  • Middle Aged
  • Nails/blood supply/ultrasonography
  • Skin/blood supply/ultrasonography
  • Skin Temperature
Citation (ISO format)
BONGARD, Olivier et al. Cyclosporine toxicity in renal transplant recipients detected by nailfold capillaroscopy with Na-fluorescein. In: Kidney international, 2000, vol. 58, n° 6, p. 2559–2563. doi: 10.1046/j.1523-1755.2000.00441.x
Main files (1)
Article (Published version)
ISSN of the journal0085-2538

Technical informations

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