Combined radioimmunotherapy and radiotherapy of liver metastases from colorectal cancer: a feasibility study

Buchegger, Franz; Allal, Abdelkarim Said; Roth, Arnaud; Papazyan, Jean-Pierre; Dupertuis, Yves Marc; Mirimanoff, R; Gillet, Marc Jean-François; Pelegrin, A; Mach, Jean-Pierre; Slosman, Daniel

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Title		Combined radioimmunotherapy and radiotherapy of liver metastases from colorectal cancer: a feasibility study
Authors		Buchegger, Franz Allal, Abdelkarim Said Roth, Arnaud Papazyan, Jean-Pierre Dupertuis, Yves Marc Mirimanoff, R Gillet, Marc Jean-François Pelegrin, A Mach, Jean-Pierre Slosman, Daniel show all authors [1 - 10]
Published in		Anticancer Research. 2000, vol. 20, no. 3B, p. 1889-96
Abstract		A combination of radioimmunotherapy (RIT) and radiotherapy (RT) should allow one to increase the dose of radiation targeting a particular tumour without the concomitant increase of toxic side effects. This might be obtained if the dose limiting side effect of each individual radiation therapy concerned different organs.
Keywords		Adult — Animals — Antibodies, Monoclonal/adverse effects/pharmacokinetics/therapeutic use — Bone Marrow Diseases/etiology — Carcinoembryonic Antigen/immunology — Colorectal Neoplasms/pathology — Combined Modality Therapy — Dose Fractionation — Drug Administration Schedule — Feasibility Studies — Female — Humans — Immunoglobulin Fab Fragments/adverse effects/therapeutic use — Iodine Radioisotopes/adverse effects/pharmacokinetics/therapeutic use — Liver Diseases/etiology — Liver Function Tests — Liver Neoplasms/radiotherapy/secondary/therapy — Male — Mice — Mice, Nude — Middle Aged — Premedication — Radioimmunotherapy/adverse effects — Radiotherapy Dosage — Radiotherapy, High-Energy/adverse effects — Tissue Distribution — Treatment Outcome
Identifiers		PMID: 10928122
Full text		Article (Published version) (2.2 MB) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine clinique / Département de chirurgie Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale
Research group		Groupe Roth Arnaud (oncologie) (285)
Citation (ISO format)		BUCHEGGER, Franz et al. Combined radioimmunotherapy and radiotherapy of liver metastases from colorectal cancer: a feasibility study. In: Anticancer Research, 2000, vol. 20, n° 3B, p. 1889-96. https://archive-ouverte.unige.ch/unige:48439