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Title

High-dose porcine hematopoietic cell transplantation combined with CD40 ligand blockade in baboons prevents an induced anti-pig humoral response

Authors
Awwad, M
Basker, M
Gojo, S
Watts, A
Treter, S
Nash, K
Oravec, G
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Published in Transplantation. 2000, vol. 69, no. 11, p. 2296-304
Abstract In pig-to-primate organ transplantation, hyperacute rejection can be prevented, but the organ is rejected within days by acute vascular rejection, in which induced high-affinity anti-Gal alpha1-3Gal (alphaGal) IgG and possibly antibodies directed against new porcine (non-alphaGal) antigenic determinants are considered to play a major role. We have explored the role of an anti-CD40L monoclonal antibody in modifying the humoral response to porcine hematopoietic cells in baboons pretreated with a nonmyeloablative regimen.
Keywords AnimalsAntibodies, Monoclonal/blood/immunology/pharmacologyAntibody Formation/drug effectsBlood/immunologyCD40 LigandCytotoxicity, ImmunologicHematopoietic Stem Cell TransplantationHumansMembrane Glycoproteins/antagonists & inhibitors/immunologyMiceMorbidityMortalityPapio/immunologySwineSwine, Miniature/immunologyTransplantation Conditioning/methodsTransplantation, Heterologous/immunology/mortality
Identifiers
PMID: 10868629
Full text
Article (Published version) (2.8 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group Cultures cellulaires et transplantations (519)
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BUEHLER, Leo Hans et al. High-dose porcine hematopoietic cell transplantation combined with CD40 ligand blockade in baboons prevents an induced anti-pig humoral response. In: Transplantation, 2000, vol. 69, n° 11, p. 2296-304. https://archive-ouverte.unige.ch/unige:48437

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Deposited on : 2015-03-25

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