Reduced cerebrovascular reactivity in young adults carrying the APOE ε4 allele

Suri, Sana; Mackay, Clare E; Kelly, Michael E; Germuska, Michael; Tunbridge, Elizabeth M; Matthews, Paul M; Ebmeier, Klaus P; Bulte, Daniel P; Filippini, Nicola; Frisoni, Giovanni

doi:10.1016/j.jalz.2014.05.1755

Scientific article

English

Reduced cerebrovascular reactivity in young adults carrying the APOE ε4 allele

ContributorsSuri, Sana; Mackay, Clare E; Kelly, Michael E; Germuska, Michael; Tunbridge, Elizabeth M; Matthews, Paul M; Ebmeier, Klaus P; Bulte, Daniel P; Filippini, Nicola; Frisoni, Giovanni

Published inAlzheimer's & dementia, vol. 11, no. 6, p. 648-657.e1

Publication date2015

Abstract

Functional magnetic resonance imaging (MRI) studies have shown that APOE ε2- and ε4-carriers have similar patterns of blood-oxygenation-level-dependent (BOLD) activation suggesting that we need to look beyond the BOLD signal to link APOE's effect on the brain to Alzheimer's disease (AD)-risk.

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de psychiatrie

Research groups

Troubles de mémoire et maladie d'Alzeimer (935)

Citation (ISO format)

SURI, Sana et al. Reduced cerebrovascular reactivity in young adults carrying the APOE ε4 allele. In: Alzheimer’s & dementia, 2015, vol. 11, n° 6, p. 648–657.e1. doi: 10.1016/j.jalz.2014.05.1755

Article (Accepted version)

Identifiers

PID : unige:48296
DOI : 10.1016/j.jalz.2014.05.1755
PMID : 25160043

Journal ISSN1552-5260

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Creation15/12/2014 12:16:00

First validation15/12/2014 12:16:00

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Reduced cerebrovascular reactivity in young adults carrying the APOE ε4 allele

Functional magnetic resonance imaging (MRI) studies have shown that APOE ε2- and ε4-carriers have similar patterns of blood-oxygenation-level-dependent (BOLD) activation suggesting that we need to look beyond the BOLD signal to link APOE's effect on the brain to Alzheimer's disease (AD)-risk.

Technical informations