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Title

Inhaled nitric oxide versus aerosolized iloprost in secondary pulmonary hypertension in children with congenital heart disease: vasodilator capacity and cellular mechanisms

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Published in Circulation. 2001, vol. 103, no. 4, p. 544-8
Abstract Inhaled nitric oxide (iNO) has been used to assess the vasodilator capacity of the pulmonary vascular bed in children with congenital heart disease and elevated pulmonary vascular resistance. Inhaled iloprost is a pulmonary vasodilator for the long-term treatment of pulmonary hypertension (PHT). Because these 2 vasodilators act through different pathways (release of cGMP or cAMP, respectively), we compared the pulmonary vasodilator capacity of each.
Keywords Administration, InhalationAerosolsAnalysis of VarianceChildChild, PreschoolCyclic AMP/bloodCyclic GMP/bloodHeart Defects, Congenital/complicationsHemodynamics/drug effectsHumansHypertension, Pulmonary/drug therapy/etiology/physiopathologyIloprost/administration & dosageInfantLung/blood supply/drug effects/physiopathologyNitric Oxide/administration & dosagePulmonary Circulation/drug effectsVascular Resistance/drug effectsVasodilator Agents/administration & dosage
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PMID: 11157720
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Article (Published version) (334 Kb) - public document Free access
Structures
Research groups Chirurgie cardio-vasculaire (105)
L'hypertension pulmonaire (pédiatrie) (228)
Maladies pulmonaires aigues et pathologies cardiaques congénitales (697)
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RIMENSBERGER, Peter et al. Inhaled nitric oxide versus aerosolized iloprost in secondary pulmonary hypertension in children with congenital heart disease: vasodilator capacity and cellular mechanisms. In: Circulation, 2001, vol. 103, n° 4, p. 544-8. https://archive-ouverte.unige.ch/unige:48154

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Deposited on : 2015-03-12

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