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Molecular and clinical characteristics in 32 families affected with familial adenomatous polyposis

Rey-Berthod, C
Couturier, A
Membrez, V
Joris, F
Schorderet, D F
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Published in Human mutation. 2001, vol. 18, no. 6, 550
Abstract Germ-line mutations in the 5' half of the Adenomatous Polyposis Coli (APC) gene are found in about 80% of the patients affected with familial adenomatous polyposis (FAP). The vast majority of these are nonsense or frameshift mutations which result in the loss of the carboxyl terminus of the APC protein. Using an in vivo assay in yeast, we have identified pathogenic germ-line mutations in 26 of 32 (81%) unrelated Swiss families affected with FAP. Nine mutations were novel and eight families were shown to harbor two recurrent mutations. Correlations were attempted between the location of APC germ-line mutations and clinical manifestations of the disease.
Keywords Adenomatous Polyposis Coli/genetics/pathologyAdenomatous Polyposis Coli Protein/geneticsAdolescentAdultChildDNA/chemistry/geneticsDNA Mutational AnalysisDNA, Complementary/chemistry/geneticsFamily HealthFemaleGerm-Line MutationHumansMaleMiddle AgedMutationPhenotype
PMID: 11748858
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Research groups Chirurgie viscérale (104)
Chirurgie viscérale (HUG)
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HUTTER, Pierre et al. Molecular and clinical characteristics in 32 families affected with familial adenomatous polyposis. In: Human mutation, 2001, vol. 18, n° 6, p. 550. doi: 10.1002/humu.1242 https://archive-ouverte.unige.ch/unige:48124

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Deposited on : 2015-03-11

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