Hepatic PTEN deficiency improves muscle insulin sensitivity and decreases adiposity in mice

Peyrou, Marion; Bourgoin, Lucie; Poher, Anne-Laure; Altirriba Gutierrez, Jorge; Maeder Garavaglia, Christine; Caillon, Aurélie; Fournier, Margot; Montet, Xavier Cédric Rodolphe; Rohner-Jeanrenaud, Françoise; Foti, Michelangelo

doi:10.1016/j.jhep.2014.09.012

Scientific article

English

Hepatic PTEN deficiency improves muscle insulin sensitivity and decreases adiposity in mice

ContributorsPeyrou, Marion; Bourgoin, Lucie; Poher, Anne-Laure; Altirriba Gutierrez, Jorge; Maeder Garavaglia, Christine; Caillon, Aurélie; Fournier, Margot; Montet, Xavier Cédric Rodolphe; Rohner-Jeanrenaud, Françoise; Foti, Michelangelo

Published inJournal of hepatology, vol. 62, no. 2, p. 421-429

Publication date2015

Abstract

PTEN is a dual lipid/protein phosphatase downregulated in steatotic liver with obesity or HCV infection. Liver-specific PTEN knockout (LPTENKO) mice develop steatosis, inflammation/fibrosis and hepatocellular carcinoma with aging, but surprisingly also enhanced glucose tolerance. This study aims at understanding the mechanisms by which hepatic PTEN deficiency improves glucose tolerance, while promoting fatty liver diseases.

Affiliation entities

Faculté de médecine / Section de médecine fondamentale / Département de physiologie cellulaire et métabolisme

Research groups

Citation (ISO format)

PEYROU, Marion et al. Hepatic PTEN deficiency improves muscle insulin sensitivity and decreases adiposity in mice. In: Journal of hepatology, 2015, vol. 62, n° 2, p. 421–429. doi: 10.1016/j.jhep.2014.09.012

Article (Published version)

Identifiers

PID : unige:47591
DOI : 10.1016/j.jhep.2014.09.012
PMID : 25234947

Journal ISSN0168-8278

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Creation05/12/2014 16:48:00

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Update14/03/2023 22:57:58

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Hepatic PTEN deficiency improves muscle insulin sensitivity and decreases adiposity in mice

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