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Scientific article
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English

Hepatic PTEN deficiency improves muscle insulin sensitivity and decreases adiposity in mice

Published inJournal of hepatology, vol. 62, no. 2, p. 421-429
Publication date2015
Abstract

PTEN is a dual lipid/protein phosphatase downregulated in steatotic liver with obesity or HCV infection. Liver-specific PTEN knockout (LPTENKO) mice develop steatosis, inflammation/fibrosis and hepatocellular carcinoma with aging, but surprisingly also enhanced glucose tolerance. This study aims at understanding the mechanisms by which hepatic PTEN deficiency improves glucose tolerance, while promoting fatty liver diseases.

Citation (ISO format)
PEYROU, Marion et al. Hepatic PTEN deficiency improves muscle insulin sensitivity and decreases adiposity in mice. In: Journal of hepatology, 2015, vol. 62, n° 2, p. 421–429. doi: 10.1016/j.jhep.2014.09.012
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ISSN of the journal0168-8278
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Creation12/05/2014 4:48:00 PM
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