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Hepatic PTEN deficiency improves muscle insulin sensitivity and decreases adiposity in mice

Publié dansJournal of hepatology, vol. 62, no. 2, p. 421-429
Date de publication2015
Résumé

PTEN is a dual lipid/protein phosphatase downregulated in steatotic liver with obesity or HCV infection. Liver-specific PTEN knockout (LPTENKO) mice develop steatosis, inflammation/fibrosis and hepatocellular carcinoma with aging, but surprisingly also enhanced glucose tolerance. This study aims at understanding the mechanisms by which hepatic PTEN deficiency improves glucose tolerance, while promoting fatty liver diseases.

Citation (format ISO)
PEYROU, Marion et al. Hepatic PTEN deficiency improves muscle insulin sensitivity and decreases adiposity in mice. In: Journal of hepatology, 2015, vol. 62, n° 2, p. 421–429. doi: 10.1016/j.jhep.2014.09.012
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Article (Published version)
accessLevelPublic
Identifiants
ISSN du journal0168-8278
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Informations techniques

Création05.12.2014 16:48:00
Première validation05.12.2014 16:48:00
Heure de mise à jour14.03.2023 22:57:58
Changement de statut14.03.2023 22:57:58
Dernière indexation16.01.2024 17:06:08
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