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Title

Hepatic PTEN deficiency improves muscle insulin sensitivity and decreases adiposity in mice

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Published in Journal of Hepatology. 2015, vol. 62, no. 2, p. 421-429
Abstract PTEN is a dual lipid/protein phosphatase downregulated in steatotic liver with obesity or HCV infection. Liver-specific PTEN knockout (LPTENKO) mice develop steatosis, inflammation/fibrosis and hepatocellular carcinoma with aging, but surprisingly also enhanced glucose tolerance. This study aims at understanding the mechanisms by which hepatic PTEN deficiency improves glucose tolerance, while promoting fatty liver diseases.
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PMID: 25234947
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Article (Published version) (1.3 MB) - public document Free access
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Research groups Obésité et syndrome métabolique (803)
Homéostasie métabolique (649)
Imagerie per-opératoire multi-modalité en radiologie interventionnelle (949)
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PEYROU, Marion et al. Hepatic PTEN deficiency improves muscle insulin sensitivity and decreases adiposity in mice. In: Journal of Hepatology, 2015, vol. 62, n° 2, p. 421-429. https://archive-ouverte.unige.ch/unige:47591

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Deposited on : 2015-03-04

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