Modulation of platelet aggregation in baboons: implications for mixed chimerism in xenotransplantation. I. The roles of individual components of a transplantation conditioning regimen and of pig peripheral blood progenitor cells

Appel, J Z (3rd); Alwayn, I P; Buehler, Leo Hans; DeAngelis, H A; Robson, S C; Cooper, D K

doi:10.1097/00007890-200110150-00020

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Title		Modulation of platelet aggregation in baboons: implications for mixed chimerism in xenotransplantation. I. The roles of individual components of a transplantation conditioning regimen and of pig peripheral blood progenitor cells
Authors		Appel, J Z (3rd) Alwayn, I P Buehler, Leo Hans DeAngelis, H A Robson, S C Cooper, D K
Published in		Transplantation. 2001, vol. 72, no. 7, p. 1299-305
Abstract		The induction of tolerance to pig antigens in primates may facilitate the development of successful clinical xenotransplantation protocols. The infusion of mobilized porcine peripheral blood leukocytes (PBPCs, comprised of approximately 2% peripheral blood progenitor cells) into splenectomized preconditioned baboons, intended to induce mixed hematopoietic cell chimerism, however, results in a severe thrombotic microangiopathy (TM) that includes pronounced thrombocytopenia. Because the mechanisms responsible for this phenomenon are unclear, we have explored the effects of individual components of the conditioning regimen, of therapeutic adjuncts, and of PBPCs on platelet aggregation.
Keywords		Animals — Hematopoietic Stem Cell Transplantation — Leukocyte Transfusion — Microcirculation — Papio — Peptides/pharmacology — Platelet Aggregation/drug effects/physiology — Platelet Aggregation Inhibitors/pharmacology — Thrombosis/etiology/physiopathology — Transplantation Chimera — Transplantation Conditioning — Transplantation, Heterologous
Identifiers		DOI: 10.1097/00007890-200110150-00020 PMID: 11602859
Full text		Article (Published version) (412 Kb) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de chirurgie
Research group		Cultures cellulaires et transplantations (519)
Citation (ISO format)		APPEL, J Z (3rd) et al. Modulation of platelet aggregation in baboons: implications for mixed chimerism in xenotransplantation. I. The roles of individual components of a transplantation conditioning regimen and of pig peripheral blood progenitor cells. In: Transplantation, 2001, vol. 72, n° 7, p. 1299-305. doi: 10.1097/00007890-200110150-00020 https://archive-ouverte.unige.ch/unige:47573