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Modulation of platelet aggregation in baboons: implications for mixed chimerism in xenotransplantation. I. The roles of individual components of a transplantation conditioning regimen and of pig peripheral blood progenitor cells |
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Published in | Transplantation. 2001, vol. 72, no. 7, p. 1299-305 | |
Abstract | The induction of tolerance to pig antigens in primates may facilitate the development of successful clinical xenotransplantation protocols. The infusion of mobilized porcine peripheral blood leukocytes (PBPCs, comprised of approximately 2% peripheral blood progenitor cells) into splenectomized preconditioned baboons, intended to induce mixed hematopoietic cell chimerism, however, results in a severe thrombotic microangiopathy (TM) that includes pronounced thrombocytopenia. Because the mechanisms responsible for this phenomenon are unclear, we have explored the effects of individual components of the conditioning regimen, of therapeutic adjuncts, and of PBPCs on platelet aggregation. | |
Keywords | Animals — Hematopoietic Stem Cell Transplantation — Leukocyte Transfusion — Microcirculation — Papio — Peptides/pharmacology — Platelet Aggregation/drug effects/physiology — Platelet Aggregation Inhibitors/pharmacology — Thrombosis/etiology/physiopathology — Transplantation Chimera — Transplantation Conditioning — Transplantation, Heterologous | |
Identifiers | PMID: 11602859 | |
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Research group | Cultures cellulaires et transplantations (519) | |
Citation (ISO format) | APPEL, J Z (3rd) et al. Modulation of platelet aggregation in baboons: implications for mixed chimerism in xenotransplantation. I. The roles of individual components of a transplantation conditioning regimen and of pig peripheral blood progenitor cells. In: Transplantation, 2001, vol. 72, n° 7, p. 1299-305. doi: 10.1097/00007890-200110150-00020 https://archive-ouverte.unige.ch/unige:47573 |