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Title

Modulation of platelet aggregation in baboons: implications for mixed chimerism in xenotransplantation. I. The roles of individual components of a transplantation conditioning regimen and of pig peripheral blood progenitor cells

Authors
Appel, J Z (3rd)
Alwayn, I P
DeAngelis, H A
Robson, S C
Cooper, D K
Published in Transplantation. 2001, vol. 72, no. 7, p. 1299-305
Abstract The induction of tolerance to pig antigens in primates may facilitate the development of successful clinical xenotransplantation protocols. The infusion of mobilized porcine peripheral blood leukocytes (PBPCs, comprised of approximately 2% peripheral blood progenitor cells) into splenectomized preconditioned baboons, intended to induce mixed hematopoietic cell chimerism, however, results in a severe thrombotic microangiopathy (TM) that includes pronounced thrombocytopenia. Because the mechanisms responsible for this phenomenon are unclear, we have explored the effects of individual components of the conditioning regimen, of therapeutic adjuncts, and of PBPCs on platelet aggregation.
Keywords AnimalsHematopoietic Stem Cell TransplantationLeukocyte TransfusionMicrocirculationPapioPeptides/pharmacologyPlatelet Aggregation/drug effects/physiologyPlatelet Aggregation Inhibitors/pharmacologyThrombosis/etiology/physiopathologyTransplantation ChimeraTransplantation ConditioningTransplantation, Heterologous
Identifiers
PMID: 11602859
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Research group Cultures cellulaires et transplantations (519)
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APPEL, J Z (3rd) et al. Modulation of platelet aggregation in baboons: implications for mixed chimerism in xenotransplantation. I. The roles of individual components of a transplantation conditioning regimen and of pig peripheral blood progenitor cells. In: Transplantation, 2001, vol. 72, n° 7, p. 1299-305. https://archive-ouverte.unige.ch/unige:47573

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Deposited on : 2015-03-04

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