• Home
  1. Home
  2. Modulation of platelet aggregation in baboons: implications for mixed chimerism in xenotransplantation. I. The roles of individual components of a transplantation conditioning regimen and of pig peripheral blood progenitor cells
Scientific article
English

Modulation of platelet aggregation in baboons: implications for mixed chimerism in xenotransplantation. I. The roles of individual components of a transplantation conditioning regimen and of pig peripheral blood progenitor cells

Contributors

Appel, J Z (3rd); Alwayn, I P; Buehler, Leo Hans; DeAngelis, H A; Robson, S C; Cooper, D K

Published in

Transplantation, vol. 72, no. 7, p. 1299-1305

Publication date

2001

Abstract

The induction of tolerance to pig antigens in primates may facilitate the development of successful clinical xenotransplantation protocols. The infusion of mobilized porcine peripheral blood leukocytes (PBPCs, comprised of approximately 2% peripheral blood progenitor cells) into splenectomized preconditioned baboons, intended to induce mixed hematopoietic cell chimerism, however, results in a severe thrombotic microangiopathy (TM) that includes pronounced thrombocytopenia. Because the mechanisms responsible for this phenomenon are unclear, we have explored the effects of individual components of the conditioning regimen, of therapeutic adjuncts, and of PBPCs on platelet aggregation.

Keywords

  • Animals
  • Hematopoietic Stem Cell Transplantation
  • Leukocyte Transfusion
  • Microcirculation
  • Papio
  • Peptides/pharmacology
  • Platelet Aggregation/drug effects/physiology
  • Platelet Aggregation Inhibitors/pharmacology
  • Thrombosis/etiology/physiopathology
  • Transplantation Chimera
  • Transplantation Conditioning
  • Transplantation, Heterologous

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

APPEL, J Z (3rd) et al. Modulation of platelet aggregation in baboons: implications for mixed chimerism in xenotransplantation. I. The roles of individual components of a transplantation conditioning regimen and of pig peripheral blood progenitor cells. In: Transplantation, 2001, vol. 72, n° 7, p. 1299–1305. doi: 10.1097/00007890-200110150-00020

Main files (1)

Article (Published version)

Identifiers

Journal ISSN

0041-1337
516views
0downloads

Technical informations

Creation

25/02/2015 14:05:00

First validation

25/02/2015 14:05:00

Update

14/03/2023 22:57:48

Status update

14/03/2023 22:57:48

Last indexation

30/10/2024 23:14:43
All rights reserved by Archive ouverte UNIGE and the University of Geneva
OpenAIRE Indexed & Validated