en
Scientific article
English

Modulation of platelet aggregation in baboons: implications for mixed chimerism in xenotransplantation. I. The roles of individual components of a transplantation conditioning regimen and of pig peripheral blood progenitor cells

Published inTransplantation, vol. 72, no. 7, p. 1299-1305
Publication date2001
Abstract

The induction of tolerance to pig antigens in primates may facilitate the development of successful clinical xenotransplantation protocols. The infusion of mobilized porcine peripheral blood leukocytes (PBPCs, comprised of approximately 2% peripheral blood progenitor cells) into splenectomized preconditioned baboons, intended to induce mixed hematopoietic cell chimerism, however, results in a severe thrombotic microangiopathy (TM) that includes pronounced thrombocytopenia. Because the mechanisms responsible for this phenomenon are unclear, we have explored the effects of individual components of the conditioning regimen, of therapeutic adjuncts, and of PBPCs on platelet aggregation.

Keywords
  • Animals
  • Hematopoietic Stem Cell Transplantation
  • Leukocyte Transfusion
  • Microcirculation
  • Papio
  • Peptides/pharmacology
  • Platelet Aggregation/drug effects/physiology
  • Platelet Aggregation Inhibitors/pharmacology
  • Thrombosis/etiology/physiopathology
  • Transplantation Chimera
  • Transplantation Conditioning
  • Transplantation, Heterologous
Citation (ISO format)
APPEL, J Z (3rd) et al. Modulation of platelet aggregation in baboons: implications for mixed chimerism in xenotransplantation. I. The roles of individual components of a transplantation conditioning regimen and of pig peripheral blood progenitor cells. In: Transplantation, 2001, vol. 72, n° 7, p. 1299–1305. doi: 10.1097/00007890-200110150-00020
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0041-1337
438views
0downloads

Technical informations

Creation25/02/2015 14:05:00
First validation25/02/2015 14:05:00
Update time14/03/2023 22:57:48
Status update14/03/2023 22:57:48
Last indexation16/01/2024 17:05:42
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack