Pig kidney transplantation in baboons: anti-Gal(alpha)1-3Gal IgM alone is associated with acute humoral xenograft rejection and disseminated intravascular coagulation

Buehler, Leo Hans; Yamada, K; Kitamura, H; Alwayn, I P; Basker, M; Appel, J Z (3rd); Colvin, R B; White-Scharf, M E; Sachs, D H; Robson, S C; Awwad, M; Cooper, D K

doi:10.1097/00007890-200112150-00007

Scientific article

English

Pig kidney transplantation in baboons: anti-Gal(alpha)1-3Gal IgM alone is associated with acute humoral xenograft rejection and disseminated intravascular coagulation

ContributorsBuehler, Leo Hans; Yamada, K; Kitamura, H; Alwayn, I P; Basker, M; Appel, J Z (3rd); Colvin, R B; White-Scharf, M E; Sachs, D H; Robson, S C; Awwad, M; Cooper, D K

Published inTransplantation, vol. 72, no. 11, p. 1743-1752

Publication date2001

Abstract

Kidneys harvested from miniature swine or pigs transgenic for human decay-accelerating factor (hDAF) were transplanted into baboons receiving an anti-CD154 monoclonal antibody (mAb) and either a whole body irradiation (WBI)- or cyclophosphamide (CPP)-based immunosuppressive regimen.

Keywords

Acute Disease
Animals
Animals, Genetically Modified/genetics
Antibodies/analysis
Antibody Formation
Antigens, CD55/genetics
Blood Coagulation
Disaccharides/immunology
Disseminated Intravascular Coagulation/blood/immunology
Graft Rejection/immunology/pathology
Graft Survival
Humans
Immunoglobulin M/analysis/immunology
Kidney/pathology
Kidney Transplantation/immunology
Papio
Swine
Swine, Miniature
Time Factors
Transplantation, Heterologous/immunology
Ureter/pathology/transplantation

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de chirurgie

Research groups

Cultures cellulaires et transplantations (519)

Citation (ISO format)

BUEHLER, Leo Hans et al. Pig kidney transplantation in baboons: anti-Gal(alpha)1-3Gal IgM alone is associated with acute humoral xenograft rejection and disseminated intravascular coagulation. In: Transplantation, 2001, vol. 72, n° 11, p. 1743–1752. doi: 10.1097/00007890-200112150-00007

Article (Published version)

Identifiers

PID : unige:47549
DOI : 10.1097/00007890-200112150-00007
PMID : 11740383

Journal ISSN0041-1337

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Pig kidney transplantation in baboons: anti-Gal(alpha)1-3Gal IgM alone is associated with acute humoral xenograft rejection and disseminated intravascular coagulation

Kidneys harvested from miniature swine or pigs transgenic for human decay-accelerating factor (hDAF) were transplanted into baboons receiving an anti-CD154 monoclonal antibody (mAb) and either a whole body irradiation (WBI)- or cyclophosphamide (CPP)-based immunosuppressive regimen.

Technical informations