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Title

Pig kidney transplantation in baboons: anti-Gal(alpha)1-3Gal IgM alone is associated with acute humoral xenograft rejection and disseminated intravascular coagulation

Authors
Yamada, K
Kitamura, H
Alwayn, I P
Basker, M
Appel, J Z (3rd)
Colvin, R B
White-Scharf, M E
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Published in Transplantation. 2001, vol. 72, no. 11, p. 1743-52
Abstract Kidneys harvested from miniature swine or pigs transgenic for human decay-accelerating factor (hDAF) were transplanted into baboons receiving an anti-CD154 monoclonal antibody (mAb) and either a whole body irradiation (WBI)- or cyclophosphamide (CPP)-based immunosuppressive regimen.
Keywords Acute DiseaseAnimalsAnimals, Genetically Modified/geneticsAntibodies/analysisAntibody FormationAntigens, CD55/geneticsBlood CoagulationDisaccharides/immunologyDisseminated Intravascular Coagulation/blood/immunologyGraft Rejection/immunology/pathologyGraft SurvivalHumansImmunoglobulin M/analysis/immunologyKidney/pathologyKidney Transplantation/immunologyPapioSwineSwine, MiniatureTime FactorsTransplantation, Heterologous/immunologyUreter/pathology/transplantation
Identifiers
PMID: 11740383
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Article (Published version) (3.9 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group Cultures cellulaires et transplantations (519)
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(ISO format)
BUEHLER, Leo Hans et al. Pig kidney transplantation in baboons: anti-Gal(alpha)1-3Gal IgM alone is associated with acute humoral xenograft rejection and disseminated intravascular coagulation. In: Transplantation, 2001, vol. 72, n° 11, p. 1743-52. https://archive-ouverte.unige.ch/unige:47549

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Deposited on : 2015-03-04

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