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Pig kidney transplantation in baboons: anti-Gal(alpha)1-3Gal IgM alone is associated with acute humoral xenograft rejection and disseminated intravascular coagulation

Publié dansTransplantation, vol. 72, no. 11, p. 1743-1752
Date de publication2001
Résumé

Kidneys harvested from miniature swine or pigs transgenic for human decay-accelerating factor (hDAF) were transplanted into baboons receiving an anti-CD154 monoclonal antibody (mAb) and either a whole body irradiation (WBI)- or cyclophosphamide (CPP)-based immunosuppressive regimen.

Mots-clés
  • Acute Disease
  • Animals
  • Animals, Genetically Modified/genetics
  • Antibodies/analysis
  • Antibody Formation
  • Antigens, CD55/genetics
  • Blood Coagulation
  • Disaccharides/immunology
  • Disseminated Intravascular Coagulation/blood/immunology
  • Graft Rejection/immunology/pathology
  • Graft Survival
  • Humans
  • Immunoglobulin M/analysis/immunology
  • Kidney/pathology
  • Kidney Transplantation/immunology
  • Papio
  • Swine
  • Swine, Miniature
  • Time Factors
  • Transplantation, Heterologous/immunology
  • Ureter/pathology/transplantation
Citation (format ISO)
BUEHLER, Leo Hans et al. Pig kidney transplantation in baboons: anti-Gal(alpha)1-3Gal IgM alone is associated with acute humoral xenograft rejection and disseminated intravascular coagulation. In: Transplantation, 2001, vol. 72, n° 11, p. 1743–1752. doi: 10.1097/00007890-200112150-00007
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Article (Published version)
accessLevelRestricted
Identifiants
ISSN du journal0041-1337
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Création03/03/2015 14:55:00
Première validation03/03/2015 14:55:00
Heure de mise à jour14/03/2023 22:57:35
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